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DATB > elm 1.2 > Flashcards

elm 1.2 Flashcards

1
Q

GABA is most important transmitter in the

A

brain

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2
Q

glycine is the most important transmitter in the

A

spinal cord

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3
Q

GAD is a

A

good histochemical marker

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4
Q

GABAa is ionotropic/metabotrophic

A

ionotropic

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5
Q

GABAb is ionotropic/metabotrophic

A

metabotrophic

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6
Q

Gat 2 or 3 does what

A

takes GABA to astrocyte

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7
Q

____% of all CNS neurons are GABAergic

A

20

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8
Q

GABA binding to GABAa receptors does what

A

increases chloride permeability

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9
Q

what are some compounds that enhance GABAa receptor function?

A

sedatives, anxiolytics, anticonvulsants

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10
Q

what are some compounds that decrease GABAa receptor function?

A

convulsants, anxiogenics

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11
Q

what is ambient GABA

A

GABA that has leaked out of synapses

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12
Q

what receptors can respond to ambient GABA? and what does this binding do?

A

extrasynaptic GABAa receptors
produces toxic inhibition

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13
Q

GABAb receptors are found _________

A

pre- or post- synaptically

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14
Q

family C G-couple protein receptors act to _____ voltage gated Ca2+ channels which in turn _____ transmitter release

A

inhibit
inhibit

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15
Q

family c gpcr also ac to open ____ channels which ____ post-synaptic excitability

A

potassium
reduces

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16
Q

family c gpcr also _____ adenylyl cyclase via ___

A

inhibit
Gi

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17
Q

GlyR is a

A

cys-loop receptor

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18
Q

what is the structure of glycine?

A

3 alpha
1 beta
subunits

19
Q

what are renshaw cells?

A

spinal cord interneurons

20
Q

renshaw cells are stimulated by collaterals from _______ _____ neurons

A

alpha motor

21
Q

renshaw cells ____ glycine onto ____ and ____ neurons

A

release
motor
inhibitory

22
Q

rendshaw cells have a ____ feedback regulation of motor neurons

A

negative

23
Q

____ is the most abundant neurotransmitter in the cns

A

glutamate

24
Q

glutamate is metabolized into ____ by _____

A

GABA
GAD

25
Q

EAAT (_________) mops up Glu into _____ and _____

A

excitatory amino acid transporter
neurons and astrocytes

26
Q

ionotropic receptors have ___ (LGIC)

A

ligand gated ion channels

27
Q

metabotropic receptors have ____ (GPCR)

A

family c GPCRs

28
Q

family c GPCRs are linked by _____

A

c terminal tails

29
Q

which are faster? ionotropic or metabotropic receptors?

A

ionotropic

30
Q

ionotropic receptors have __ transmembrane domains and __ agonist binding sites

A

3
4

31
Q

how many groups of metabotropic receptors are there?

A

3

32
Q

what diseases are ionotropic receptors involved in?

A

schizophrenia, AD, parkinsons, stroke

33
Q

metabotropic receptors have a ____ domain at the ___ terminus

A

venus fly trap
n

34
Q

AMPA receptors mediate ______

A

fast synaptic transmission

35
Q

AMPA receptors have ___ subunits, and each binds ___ but they need ___ to be occupied in order to be activated

A

4
glutamate
2

36
Q

Kainate receptors can act similarly to ___ receptors but are much _____ widespread, and can be found on ___ synaptic terminals

A

AMPA
less
pre

37
Q

kainate receptor permeability to Ca2+ is much ____ than some AMPA receptors

A

less

38
Q

NMDA receptors are very / not permeable to Ca2+

A

very

39
Q

NMDA receptors are blocked by ____ at ____

A

Mg2+
RMP

40
Q

when NMDA receptors are blocked by Mg, it leads to ____ which allows _____ and ____ the NMDA receptor

A

depolarization
ion flux
de-inactivates

41
Q

NMDA receptors need _____ or ______ as a coagonist

A

glycine
D-serine

42
Q

what kind of receptor is a rich target for drugs?

A

NMDA receptors

43
Q

Acetylcholine is released through ____ dependent processes

A

Ca2+

DATB (24 decks)

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