elm 8.2 Flashcards
what are the two types of monoamine oxidases?
a and b but a is more important
a: 5HT, NA, dopamine
b: primarily dopamine - located on outer mitochondrial membrane
tyramine is normally broken down in the ____ by ____. this might be linked to ____
liver
MAO
migraines
tyramine also sometimes acts as a fake substrate for ______
NET
serotonin syndrome is when there is a massive _____ in synaptic serotonin, which causes ….
increase
confusion, agitation, muscle twitching, sweating, seizures, arrhythmias, coma etc
newer MAOI are selective for ________, and are irreversible / reversible.
MAO-A
reversible
SSRI is what
selective serotonin reuptake inhibitors
SNRI is what
serotonin/noradrenaline reuptake inhibitors
what is an example of an SSRI
fluoxetine (prozac)
what is an example of an SNRI
duloxetine
what is an example of an NRI
reboxetine
what are unwanted effects of SSRI/SNRI/NRI’s?
nausea, anorexia, insomnia, discontinuation syndrome, sexual side effects
increased aggression, suicide ideation
______ is the only SSRI recommended by NICE for young people (it’s still used with caution and after other therapies)
fluoxetine
tricyclic antidepressants have pronouned effects at ____, _____ receptors, _____ receptors, ___ adrenergic
mAChR
H
5HT
alpha 1
what is an example of a tricyclic antidepressant?
imipramine
what is antidepressant discontinuation syndrome
flu-like
duloxetine amongst worst for discontinuation syndrome
brain zaps
