Electron Transport Chain

Question 1

Name the components of the ETC

Answer 1

1. FMN
2. Fe-S centers
3. Coenzyme Q
4. Cytochromes b, c1, c, and aa3

Question 2

Cyanide poisonong binds Fe3+ in cytochorme ____ resulting to ___

Answer 2

Cyt AA3, blocks O2 as final electron acceptor

Question 3

NADH passes electrons via ____ while FMN passes the electrons to a series of ____ complexes

Answer 3

NADH : complex I )NADH dehydrogenase complex) to GMN

FMN to Fe-S complexes to Coenzyme Q

Question 4

Coenzyme q passes the electrons through Fe-S centers to cytochromes ____ and ___ which transfers these electrons to cytochrome ____

Answer 4

CoQ to b and c1 then to cyt C

Question 5

Electrons from FADH2 enter the ETC at ____ which contains ____ enzyme.

Answer 5

complex II, succinate dehydrogenase

Question 6

Cytochrome oxidase ___ catalyzes the transfer of electrons from cyt C to cyt aa3 complex

Answer 6

IV

Question 7

___ mineral that is present cytochromes a and a3

Answer 7

copper

Question 8

(Inhibitor of ETC) ____ complexes with complex I causing NADH accumulation

Answer 8

Rotenone (rotenONE)

Amytal

Question 9

(inhibitor of ETC) ___ block the passage of electrons through the cyt b-c1 complex III

Answer 9

Antimycin (antimicin = 3 i = iii = complex 3)

Question 10

(inhibitor of ETC) _____ and ____ block complex IV

Answer 10

Cyanide and CO

Question 11

(inhibitor of AT synthesis) ____ inhibits ANT resulting to lack of ADP in the mitochondrial matrix

Answer 11

Atracycloside

Question 12

____ is an uncoupler since it allows protons from the cytosol to reenter the matrix without going through the ATP synthase complex

Answer 12

dinitrophenol

Question 13

(deletion of contiguous segment of tRNA and OXPHOS) ___ syndrome ophthalmoplegia, atypical retinitis pigmentosa, mitochondrial myopathy, cardiac conduction defect, cerebellar syndrome, elevated CSF

Answer 13

Kearns-Sayre syndrome

Question 14

(mtDNA missense mutation) ___ disease optic atrophy, ophthalmoplegia, nystagmus, respiratory abnormalities, ataxia, hypotonia, spasticity, develpmental delay, regression

Answer 14

leigh disease

Question 15

Glutathione is composed of ___ amino acids.

Answer 15

gamma-glutamyl-cysteine-glycine