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Biochemistry > Complex Molecules > Flashcards

Complex Molecules Flashcards

1
Q

Oligosacharides attach to this AA and O-linked to make glycoprotein

A

Serine

Mnemonic = OG SER

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2
Q

Oligosachides attached to serine to form glycoprotein is synthesized in the ___

A

golgi bodies

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3
Q

Oligosaccharides attached to this AA is N-linked (to make glycoprotein)

A

Asparagine

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4
Q

Oligosaccharide attached to asparagine to make glycoprotein is synthesized in the

A

Endoplasmic reticulum

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5
Q

Cell surface antigenicity is due to what complex molecule?

A

Glycoprotein

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6
Q

[Complex molecule]

Transport proteins with glycoprotein

A

Transferrin

Ceruloplasmin

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7
Q

[Complex molecule]

Hormone that contains glycoprotein

A

HCG, TSH

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8
Q

[Complex molecule]

lubricant protective int he GIT and urogenital tract that has glycoprotein

A

mucin

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9
Q

[Complex molecule]

Glycosaminoglycans is mostly made of

A

CHO

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10
Q

Glycosaminoglycas are unbranced polysaccharides consisting of alternating ___-

A

acidic sugar-aminosugar

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11
Q

[Glycosaminoglycans]

What are examples of acid sugars

A

Glucuronic Acid

Iduronic acid

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12
Q

[Glycosaminoglycans]

examples of amino sugar

A

Glucosamine

Galactosamine

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13
Q

Which GAG is not linked to a proteoglycan core

A

hyaluronic acid

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14
Q

[Glycosaminoglycans]

Needed for cell migration and wound repair

A

hyaluronic acid

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15
Q

[Glycosaminoglycans]

seen in carilage

A

Chondroitin sulfate

most abundant

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16
Q

[Glycosaminoglycans]

maintains corneal transparency

A

keratan sulfate

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17
Q

[Glycosaminoglycans]

anticoagulat

A

heparin

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18
Q

[Glycosaminoglycans]

receptor for cell growth and cell-cell communication

A

heparan sulfate

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19
Q

[Glycosaminoglycans]

maintain GAG of skin

A

dermatan sulfate

20
Q

[Glycerophospholipids]

What bond maintains the binding of an R-OH to the diacylglycerol

A

Phosphodiester bind

21
Q

[Glycerophospholipids]

Most abundant glycerophospholipid

A

lecithin

22
Q

[Glycerophospholipids]

storage of choline component of acetylcholine

A

Phosphatidylcholine

23
Q

[Glycerophospholipids]

cephalin, cell membrane inner leaflet

A

phosphatidylethanolamine

24
Q

[Glycerophospholipids]

plays a role in apoptosis

A

Phosphatidylserine

25
Q

[Glycerophospholipids]

reservoir of arachidonic acid in cell membrane

A

phosphatidylinositol

26
Q

[Glycerophospholipids]

source of inositol triphosphate + DAG

A

phosphatidylinositol

27
Q

[Glycerophospholipids]

lung surfactant

A

Dipalmitoyllecithin

28
Q

[Glycerophospholipids]

cross reacts with antibodies to syphilis

A

Cardiolipin

29
Q

What is the backbone of sphingophospholipids?

A

Sphingosine

30
Q

What is the only significant sphingophospholipid in humans?

A

Sphingomyelin

31
Q

___ is a complex molecule that is a derivative of ceramide in which a long chain FA is attached to sphingosine backbone

A

Glycosphingolipids

32
Q

[Glycosphingolipids]

if hyrdogen atom is ttached

A

Ceramide

33
Q

[Glycosphingolipids]

if glucose or galactose is attached

A

Cerebroside

34
Q

[Glycosphingolipids]

if a di-, tri-, or tetrasaccharide is attached

A

globoside

35
Q

[Glycosphingolipids]

if N-acetylneuraminic acid is attached

A

ganglioside

36
Q

[Glycosphingolipids]

if sulfated glucose is attached

A

sulfatide

37
Q

What contributes to the asymmetry of the cell membrane outer leaflet?

A

glycosphingolipids

38
Q

___ are derived from 20 carbon FA arachidonic acid, cleaved by phospholipase A2

A

Eicosanoid

39
Q

What enzyme produces prostaglandin and thromboxane?

A

Cyclooxygenase

40
Q

What enzyme produces leukotrienes?

A

lipooxygenase

41
Q

[Eicosanoids]

protect gastric mucosa

A

prostaglandin

42
Q

[Eicosanoids]

Promotes platelet adhesion and aggregation

A

Thromboxane

43
Q

[Eicosanoids]

stimulate vasodilation, inhibits thrombosis

A

Prostacyclin

44
Q

[Eicosanoids]

Keeps PDA patent, used for erectile dysfunction

A

Alprostadil (PGE1)

45
Q

[Eicosanoids]

Results in vasodilation and relaxation of smooth muscle used to induce labor

A

Prostaglandin E2

46
Q

[Eicosanoids]

results in vasoconstriction and contraction of muscle, stimulates uterine contraction

A

PGF2alpha

47
Q

[Eicosanoids]

slow reacting substances,

potent airway constrictors

A

LTC4
LTD4
LTE4

Biochemistry (28 decks)

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