Drug - Drug Interactions

Question 1

What is a drug interaction?

Answer 1

The modification of a drug effect by prior or concomitant administration of another substance

Question 2

What things could cause an interaction with another drug?

Answer 2

Food, drink, drug, herbal

Question 3

what is the object drug?

Answer 3

The drug which is effected by a substance

Question 4

What is the precipitant?

Answer 4

A substance that effects the drug’s work

Question 5

What is drug to drug interaction beneficial?

Answer 5

treatment of hypertension

Question 6

what is a quality of drugs that have serious interaction effects ?

Answer 6

They tend to have a narrow therapeutic index

Question 7

what foods can have an interaction with drugs?

Answer 7

Asparagus, spinach, broccoli, lettuce, green tea. etc

Question 8

what are some susceptible patients to drug - drug interactions?

Answer 8

older, ill, young, big surgical procedure

Question 9

Name 5 conditions that will make someone susceptible to drug - drug interactions.

Answer 9

Liver disease, renal impairment, diabetes mellitus, epilepsy and asthma

Question 10

What is meant by marked inter-individual variation?

Answer 10

people might have completely different reactions to drug - drug interactions.

Question 11

Drugs can affect absorption of others. When may this be particularly bad.

Answer 11

If the aborbtion is slowed down when drugs have a short half life or if we want high plasma levels fast/

Question 12

Give an example of drugs binding together in the GI tract

Answer 12

ethrymycin + calcium/iron/magnesium

Question 13

what reduces H+ which increases the PH and affects drug absorption?

Answer 13

H2 antagonists, proton pump blockers, antacids

Question 14

what could a change in the GI bacterial flora lead too?

Answer 14

failure of oral contraceptive

Question 15

drugs that affect GI motility affect the rate limiting step of absorption what is this?

Answer 15

gastric emptying

Question 16

increasing gastric emptying can lead to faster absorption of what?

Answer 16

Paracetamol

Question 17

How can drug -drug interaction affect distribution? explain

Answer 17

protein -rpotein displacement

One drug displaces other on protein and the drug that is displaced has more bioavailability

Question 18

How is the patient protected by protein - protein displacement?

Answer 18

increased metabolism and excretion

Question 19

How can drug - drug interactions affect metabolism

Answer 19

one drug can inhibit/induce metabolism of another

Question 20

Give an example of metabolism being affected by drug- drug interaction, induce and inhibit.

Answer 20

inhibit - macrolides inhibit cytochrome P450

Induce - tobacco induces cytochrome P450

Question 21

what ways can pharmacodynamic be affected by drug - drug interaction ?

Answer 21

directly, indirectly, antagonist, synergist, addictive.

Question 22

Give an example of direct antagonism.

Answer 22

beta - blockers block site for salbutamol

Question 23

How do you deal with drug - drug interaction?

Answer 23

Alter dose times

If this doesn’t work, adjust doses and monitor drug levels and physiological function