Chronic Inflammation 2

Question 1

Does cleanliness promote or impair wound healing?

Answer 1

Promote.

Question 2

Does a gaping hole promote or impair wound healing?

Answer 2

Impairs.

Question 3

What does apposition of edges mean, and does it promote or impair wound healing?

Answer 3

It means the edges of the wound made close together (perhaps by stitches ) promotes wound healing.

Question 4

What are coagulation mechanisms?

Answer 4

Clotting mechanisms.

Question 5

What is a haemotoma, and does it promote or impair healing?

Answer 5

A solid swelling of clotted blood within tissues - impairs healing.

Question 6

Does good nutrition and metabolic stability promote or impair healing?

Answer 6

Promote.

Question 7

Impaired healing can be caused by lacking which vitamins?

Answer 7

A & C

Question 8

What condition can impair healing?

Answer 8

Diabetes

Question 9

Which drugs for arthritis can impair healing?

Answer 9

Corticosteroid drugs.

Question 10

What is angiogenesis? Why is it important?

Answer 10

Creation of new blood vessels. enzyme secretion aids process. It enables blood supply to enter damaged tissue.

Question 11

What are the characteristics of granulomatous inflammation ?

Answer 11

Granuloma in tissues and organs.

Question 12

Why do granulomas form?

Answer 12

Granulomas form when the immune system attempts to wall off substances it perceives as foreign but is unable to eliminate.

Question 13

What are granulomas?

Answer 13

Collection of macrophages. May contain giant cells. Surrounded by dead tissue and lymphocytes. Contains neutrophils and eosinophils.

Question 14

What are giant cells?

Answer 14

Cells which are fused macrophages.

Question 15

Name some causes of Granulomatous inflammation.

Answer 15

Foreign body, silicone associated, laghans type (TB), Warthog-Finkeldy type (seen is measles rarely)

Question 16

Laghans type has a large easinophillic cytoplasm. What does this mean?

Answer 16

Can be readily stayed by eosin. A type of staining used in histology.

Question 17

Foreign bodies are said to be associated with pyogenic granulation tissue. What does this mean?

Answer 17

Production of pus in granulation tissue.

Question 18

Name 3 Infectious granulomatous diseases?

Answer 18

TB, Leprosy and syphillis.

Question 19

Name 3 non - infective granulomas .

Answer 19

Rethumatoid disease
Sarcoidosis
Crohn’s disease.

Question 20

Surgical wound healing - what is primary intention?

Answer 20

Minimal gap - small about of granulation tissue - small linear scar.
wound held together by stitches.

Question 21

What is healing by secondary intention?

Answer 21

Large wound, lots of granulation tissue growth, lots of scarring.
Dressing applied regularly , heals gradually from inside.

Question 22

Fracture healing occurs similarly to any type of wound healing. There is a trauma, then things such as acute inflammation, organisation, macrophages removing debris etc. (Granulation tissue contains osteoblasts and well as fibroblasts). But what is callous formation?

Answer 22

Osteoblasts lay down woven bone.

Bone remodelling - osteoclasts remove dead bone etc.