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P O D Taz > Antimicrobial chemotherapy -antifungals > Flashcards

Antimicrobial chemotherapy -antifungals Flashcards

1
Q

What type of anti fungal works by binding to ergosterol

A

polyenes

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2
Q

what are two types of polyene?

A

Amphotericin B

Nystatin

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3
Q

What do polyenes work against?

A

yeast and filamentous fungi

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4
Q

What is amphotericin B used for?

A

Serious fungal infection (IV)

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5
Q

Why are polyenes toxic?

A

Can bing to cholesterol found in humans - causes them to become toxic.
Side effects - renal, hepatic, cardiac toxicity.

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6
Q

How is nystatin applied?

A

Topical

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7
Q

What sub class of anti-fungal treatment works by inhibiting the synthesis of ergosterol?

A

Azoles and Allyamines

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8
Q

What are older azoles called?

A

imidazoles

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9
Q

What are newer azoles called?

A

Triazoles

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10
Q

Name two imidazoles

A

ketoconazole

miconazoles

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11
Q

How are imidazoles administered?

A

Topically and orally

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12
Q

what do miconazoles work on?

A

internal and external infections, including yeast and dermatophytes (a type of filamentous fungus)

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13
Q

What does ketoconazole work on?

A

Topical infections

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14
Q

Name three triazoles.

A

Fluconazole,
Itraconazole,
Voriconazole

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15
Q

What do fluconazoles treat? and how?

A

Yeasts - orally and parentally

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16
Q

What do intraconazoles treat?

A

yeasts and filamentous fungi - including dermatophytes and aspergillus species

17
Q

What does voriconazole treat?

A

Aspergillosis

18
Q

Name a allyamine.

A

terbinafine

19
Q

what do terbinafines treat?

A

primarily dermatophytes

20
Q

How are terbinafines administered?

A

Mild infections - topically
Serious infections - parentally
They target a different stage of the synthetic pathway to azoles

21
Q

what type of anti fungal works by inhibiting glucanpolysaccharide synthesis?

A

echinocandins

22
Q

Name three types of echinocandins.

A

caspofungin
mycafungin
anidulafungin

23
Q

What do echinocandins work on?

A

Fungicidal - candida species

and they inhibit the growth of several aspergillus species

24
Q

What are echinocandins used for?

A

serious candida and aspergilus infections - based on specialist advice

P O D Taz (47 decks)

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