Development of Urogenital system Flashcards
urogenital system develops from
intermediate mesoderm
hindgut is from
endoderm and splanchnic mesoderm
external genitalia is from
ectoderm
source of germ cells
migratory cells from the yolk sac
what forms gonads
genital ridge
what forms primitive kidneys and ducts of reproductive tract
mesonephric ridge- caudal part, cranial part regresses
parts of the mesonephric ridge
pronephros
mesonephros
metanephros
pronephros
disappears
mesonephros
tubules and ducts for make reproductive tract
metanephros
primative kidney
uteric bud
forms collecting ducts
comes from outgrowth of mesonephric bud
metanephric blastema
formed from metanephros, makes nephrons
trigone formation
mesonephric duct joins the urogenital sinus and is absorbed, bringing the uteri bud in contact with the urogenital sinus
mesonephric duct forms
forms ductus deferens
uteric bud forms
forms ureter and collecting ducts
urogenital sinus forms
bladder
ductus deferens path
looped over the ureter as testis descends
renal agenesis
failure of kidney to develop which results in no amniotic fluid–> tight space–> deformed fetus
polycystic kidney
urine formation without proper drainage resulting in cyst formation
pelvic kidney
kidney doesn’t descend
horseshoe kidneys
kidneys fuse at midline and begin to ascend but they get stuck under the IMA
bifid ureter
2 ureters exit kidney but merge before entering the bladder
ectopic ureter
2 ureters enter the bladder
governed by Weigert-Meyer rule
weiger-Meyer rule
lower pole kidney gets to bladder first and is normal
upper pole kidney gets to bladder second and doesn’t ascend, it descends into the neck of the bladder, vagina, or rectum
hydronephrosis
high pressure
testis determining factor
on sex determining region on Y chromosome
induces sertoli cell differentiation and production of anti-mullarian hormone
anti-mullarian hormone
paramesonephric ducts regress
leydig cells differentiate and produce testosterone
testosterone role
induces mesonephric duct differentiation and testis formation
how is paramesonephric duct formed
involution of mesonephric ridge
migratory path of germ cells
yolk sac allantois across gut wall dorsal mesentary retroperitoneal space primative gonand of genital ridge
formation of primative sex cords
germ cells stimulate coelomic epithelium to proliferate and invade storm
cortex and medulla form
fate of male medulla of primitive sex cord
seminiferous tubules and straight ducts and rate testis
fate of male cortex of primitive sex cord
regresses, forms tunica albuginea
fate of female cortex of primitive sex cord
becomes follicles
fate of female medulla of primitive sex cord
regresses
uterus formation
paramesonephric ducts fuse at midline
vagina formation
upper 1/3- paramesonephric ducts
lower 2/3- urogenital sinus
remnants of the mesonephric duct in females
epoophoron and paraoophoron in mesovarium
gartner’s cyst near vagina
uterus didelphys with double vagina
2 vagina, 2 uterus
uterus arcuates
thick uterine fundus
uterus bicornis
2 uterus, 1 vagina
uterus bicornis with rudimentary horn
2 uterus but one of the is not attached
atresia of cervix
closed cervix
atresia of vagina
closed vagina
parts of hindgut
endoderm and splanchnic mesoderm
allantois becomes the
median umbilical ligament
parts of the cloaca
urogenital sinus
anorectal canal
urogenital sinus becomes
bladder, urethra, external genitalia
anorectal canal becomes
anal canal, rectum, hindgut
significance of cloacal membrane
transition between endoderm and ectoderm
persistant anal membrane
no anal openin
rectoperineal fistula
anal opening is in the wrong place, in the perineal area
rectovaginal fistula
anal opening into vagina
urorectal fistula
anal opening into urethra
parts of urogenital sinus and what they become
bladder- bladder
pelvic- membranous urethra
definitive UG sinus- vestibule of vagina or spongy urethra
genital tubercle becomes the
clitoris/penis
urethral folds become the
labia minora/spongy urethra
labia minora lining
vestibule- endoderm
ectoderm- surface
genital swellings become the
labia majora/scrotum
hypospaides
incomplete fusion of urethral folds