Development Of The Kidneys Flashcards
Wolffian ducts
Precursor of male internal sex organs
Mullerian ducts
Precursors of female internal sex organs
What part of the wolffian duct does not degenerate in females
Lower portion - forms ureteric bud
What are the 3 embryonic kidneys
Pronephric
Mesonephric
Metanephric
What duct do the kidneys form from
Mesonephric
What is the only functional embryonic kidney
Metanephric kidney
What 2 embryonic structures form the Metanephric kidney
Uteteric bud
Metanephric bud
What adult structures form from the ureteric bud
Ureter
Renal pelvis
Major and minor calyces
Collecting tubules
What adult structures form from the Metanephric bud
Renal glomerulus + capillaries
Bowman’s capsule
Proximal convoluted tubule
Loop of henle
Distal convoluted tubule
What does the kidney collecting system form from
Ureteric bud
What does the nephron form from
Metanephric bud
Do the adrenal glands ascend
No - develop in situ
Where does the Metanephric kidney develop
S1
What happens to the transitory renal arteries
Degenerate
What does a failure of the kidneys to ascend cause
Ectopic kidney
What is the most common cause of kidney agenesis
Failure of uteric bud to meet mesenchyme
Kidney agenesis
Failure of 1/both kidneys to form
What type of kidney agenesis is asymptomatic
Unilateral
Oligohydramnios
Reduction in amniotic fluid
Why does bilateral renal agenesis lead to oligohydramnios
Kidneys involved in generation of amniotic fluid
How does bilateral kidney agenesis lead to failure of lung development
Decreased amniotic fluid
Bifid ureter
Ureter splits in 2
What can a bifold ureter lead to
Duplicate kidneys
Duplicate ureter
Ectopic pelvic kidney
Kidney remains in pelvic region
Pancake kidney
Both poles of kidneys fuse creating 1 very large kidney in pelvic region with normal function
Pancake kidney symptoms
Asymptomatic
Horseshoe kidney
Kidneys fuse at 1 pole in pelvic region forming a single u shaped kidney
Why can horseshoe kidneys not ascend
Blocked by inferior mesenteric artery
Polycystic kidney
Kidney develop fluid filled cysts
What causes polycystic kidneys
Defects in formation of tubules of nephron
What mutation is the majority of polycystic kidney disease cases associated with
PKD-1
How does a kidney cyst form
Dilation of tubule -> proliferation of cyst epithelium -> cyst epithelium becomes secretory -> fluid secretion into cyst lumen -> cyst enlarged and loses contact with nephron