CV Drugs - Hypolipidemic Agents

Question 1

rate limiting step in cholesterol synthesis

Answer 1

HMG-CoA reductase

Question 2

statins

Answer 2

hmg-coa reductase inhibitor

s/e:
hepatotoxic - check AST/ALT before take
rhabdomyolysis (skeletal muscle breakdown)

Question 3

long half life hmg-coa reductase

Answer 3

atorvastatin
rosuvastatin

Question 4

cholestyramine

Answer 4

bile acid sequesterants (resins)

Question 5

colestipol

Answer 5

bile acid sequesterants (resins)

Question 6

stanol esters

Answer 6

inhibitors of intestinal absorption of cholesterol

Question 7

ezetimibe

Answer 7

inhibitors of intestinal absorption of cholesterol

Question 8

torcetrapib

Answer 8

cholesterol ester transfer protein (CETP) inhibitors

Question 9

anacetrapib

Answer 9

cholesterol ester transfer protein (CETP) inhibitors

Question 10

increases HDL

Answer 10

niacin/vit B3

Question 11

gemfibrozil

Answer 11

fenofibrates
activates ppar alpha (dec fatty acid synthesis)

Question 12

clofibrate

Answer 12

fenofibrates
activates ppar alpha (dec fatty acid synthesis)

Question 13

lipid effect: statins

Answer 13

dec ldl & triglycerides

Question 14

lipid effect: niacin

Answer 14

dec ldl & triglyceride
inc hdl

Question 15

lipid effect: fibric acid/ fenofibrates

Answer 15

dec ldl & triglyceride
inc hdl

Question 16

lipid effect: bile resins

Answer 16

dec ldl

Question 17

lipid effect: ezetimibe

Answer 17

dec ldl