CNS - Parkinsons & Opioids Flashcards
carbidopa
Cinemet
DOPA decarboxylase inh
DOPA decarboxylase - degrades L-Dopa in periphery
anti-parkinsonism
entacapone
catechol o methyl transferase (COMT) inh
COMT - degrades L-Dopa in periphery
antiparkinsonism
tolcapone
catechol o methyl transferase (COMT) inh
COMT - degrades L-Dopa in periphery & brain
antiparkinsonism
selegiline
mao-b inh
mao b = degrades dopamine in brain
antiparkinsonism
rasagiline
mao-b inh
mao b = degrades dopamine in brain
antiparkinsonism
pramipexole
dopaminergic agonist
antiparkinsonism
ropinirole
dopaminergic agonist
antiparkinsonism
bromocriptine
dopaminergic agonist
antiparkinsonism
pergolide
dopaminergic agonist
antiparkinsonism
amantadine
Symmetrel (antiviral)
release dopamine in unaffected neurons
s/e: livedo reticularis (purple rash)
antiparkinsonism
benztropine
Cogentin
centrally acting anticholinergic
dec Ach = no contraction of Nm
antiparkinsonism
receptor for psychomimetic effects of opioid
kappa
receptor for ddiction/dependence a of opioid
mu
receptor for sedation of opioid
kappa
receptor for euphoria of opioid
mu
receptor for hallucinations of opioid
sigma
opioid moa
dec camp (looks like a2)
morphine
strong/full agonist
opioid
methadone
strong/full agonist
opioid
meperidine
strong/full agonist
opioid
fentanyl
short acting but more potent than morphine
strong/full agonist
opioid
codeine
dextrometorphan
moderate/partial agonist
opioid
oxycodone
hydrocodone
moderate/partial agonist
opioid
propoxyphene
weak agonist
opioid
