CV Drugs - Heart Failure Flashcards
HF: pulmonary congestion
left side heart failure
insufficient blood in organs = organ failure
lethargy, left ventricular hypertrophy (cardiomegaly)
HF: ascites
right side heart failure
liver and spleenic congestion
edema in feet, no appetite
positive intoropic drugs
cardiac glycosides
beta agonists
pde 3 inhibitors
vasodilators
nitroprusside, nitrates, hydralazine
pde 3 inhibitors
loop diuretics, ACE (-)/ARBS, nesiritide
miscellanoues drugs for chronic failure
loop diuretics (for edema)
ACEI/ARBS, nesiritide, spironolactone (prevent cardiac remodelling)
beta blockers (metoprolol, bisoprolol, carvedilol)
inhibits Na-K atpase
digoxin
cardiac glycoside
+ inotropic drugs
S/E: anorexia, insomnia, yellow vision
arrhythmia (tx: lidocaine, phenytoin)
worsens digoxin toxicity
hypoK
hyperCa
hypoMg
beta agonist for HF
dobutamine
pde -3 inhibitors
pde -3 degrades CAMP
+ inotropic drugs & vasodilator
milrinone
inamrinone
stimulates guanylate cyclase
GTP -> CGMP
nitroprusside
nitrates
causes reflex tachycardia to compensate low BP
vasodilator
S/E: monday sickness
nitrates
causes headache but fast tolerance
vasodilators
hydralazine
vasodilator
analogue of brain natriuretic peptide (BNP)
nesiritide
misc drugs & vasodilator
metoprolol
slows HR
CI: acute failure
beta blocker
misc for chronic failure
bisoprolol
slows HR
CI: acute failure
beta blocker
misc for chronic failure
