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MOD 4 - Pharmacology > CV Drugs - Antiplatelet & Anticoagulants > Flashcards

CV Drugs - Antiplatelet & Anticoagulants Flashcards

1
Q

formation of platelet plug

A
  1. platelet adhesion
  2. platelet activation
  3. platelet aggregation
  4. platelet plug formation
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2
Q

pampalabnaw ng dugo

A

CAMP (degraded by PDE)

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3
Q

activates platelet

A

thromboxane A2
P2Y receptor (ADP)

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4
Q

aspirin

A

irreversible cox inhibitor

inhibits conversoin to Txa2
antiplatelet

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5
Q

trifusal

A

irreversible cox inhibitor

inhibits conversoin to Txa2
antiplatelet

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6
Q

cilostazol

A

pde (-)

increases CAMP
antiplatelet

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7
Q

dipyridamole

A

pde (-)

increases CAMP
antiplatelet

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8
Q

clopidogrel

A

P2Y antagonist
antiplatelet

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9
Q

ticlopidine

A

P2Y antagonist
antiplatelet

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10
Q

regulates platelet adhesion and aggregation

A

glycoprotein (GP) IIb & IIIa
antiplatelet

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11
Q

eptifibatide

A

glycoprotein (GP) IIb & IIIa antagonist
antiplatelet

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12
Q

tirofiban

A

glycoprotein (GP) IIb & IIIa antagonist
antiplatelet

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13
Q

monitoring: heparin

A

activated partial thromboplastin time (intrinsic) - aPTT

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14
Q

monitoring: warfarin

A

prothrombin time/ international normal ratio (PT/INR)

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15
Q

common pathway in coagulation cascade

A

Xa

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16
Q

stimulates VII production

A

TF
tissue factor/ 3

17
Q

dabigatran

A

direct thrombin inhibitor

18
Q

argatroban

A

direct thrombin inhibitor

19
Q

lepirudin

A

direct thrombin inhibitor

20
Q

heparin

A

enoxaparin
unfractioned heparin (UFH)
LMWH

indirect thrombin inhibitor

21
Q

fondaparinux

A

indirect thrombin inhibitor

22
Q

warfarin

A

vit k epoxide reductase inhibitor

vit k dependent factors:
10,9,7,2

23
Q

rivaroxaban

A

direct Xa inhibitor
aka novel oral anticoagulants (NOAC)

24
Q

apixaban

A

direct Xa inhibitor
aka novel oral anticoagulants (NOAC)

25
Q

destroys fibrin

A

plasmin
inactive: plasminogen

26
Q

clot

A

fibrin
inactive: fibrinogen

27
Q

streptokinase

A

fibrinolytic
activated tissue plasminogen activator (t-PA)

28
Q

urokinase

A

fibrinolytic
activated tissue plasminogen activator (t-PA)

29
Q

reteplase

A

analogue of alteplase

fibrinolytic
activated tissue plasminogen activator (t-PA)

30
Q

alteplase

A

fibrinolytic
activated tissue plasminogen activator (t-PA)

31
Q

tenecteplase

A

fibrinolytic
activated tissue plasminogen activator (t-PA)

32
Q

uses of fibrinolytics

A

STEMI (when cant cardiac perfusion)
ischemic stroke

MOD 4 - Pharmacology (19 decks)

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