Anti-inflammatory/ Anti-gout Flashcards
aspirin
lolo
only irreversible inhibitor of cox
NSAID: 350-500mg
antiplatelet: 80 mg
s/e: dec GI protective
non selective cox inh
ibuprofen
analgesic but low anti-inflamm
do not give w aspirin
s/e: dec GI protective
propionic derivative
non selective cox inh
ketoprofen
s/e: dec GI protective
propionic derivative
non selective cox inh
flurbiprofen
long duration
s/e: dec GI protective
adr: MI, HTN
propionic derivative
non selective cox inh
naproxen
not acidic (less GI irritation)
s/e: dec GI protective
non selective cox inh
nabumetone
ketone
s/e: dec GI protective
non selective cox inh
etodolac
used in post-op as sub to morphine
ADR: pinpoint pupil
s/e: dec GI protective
non selective cox inh
ketorolac
used in post-op as sub to morphine
ADR: pinpoint pupil
s/e: dec GI protective
non selective cox inh
sulindac
related to sulfonamides
s/e: dec GI protective
ADR: sjs
non selective cox inh
indomethacin
inhibits PLA2
for closure of patent ductus arteriosus (alt: ibuprofen IV)
s/e: dec GI protective
non selective cox inh
“coxib”
cox II selective drugs
less ADR
phased out cox II inh bc of thrombosis
lumiracoxib
valdecoxib
rofecoxib (Vioxx)
arthritis: wear and tear of joints
osteoarthritis
arthritis: autoimmunity
rheumatoid arthritis
arthritis: hyperuricemia
gouty arthritis
tx for osteoarthritis
collagen supplements
avoid strenious activities
band aid drug for arthritis
NSAIDs
tx for chemotaxis
disease modifying antirehumatic drugs
immunosuppression
abatacept
target cd80 & cd86
DMARD
azathioprine
converted to 6-thioguanine
(-) dna synthesis
DMARD
cyclophosphamide
alkylating agent; anticancer
dna breakage
adr: hemorrhagic cystitis (rescue drug: MESNA)
DMARD
cyclosporine
targets calcineurin
adr: hirsutism, gingival hyperplasia
DMARD
chloroquine/hydrochloroquine
antimalarial
first investigational drug against COVID
DMARD
leflunomide
(-) dihydroorotate dehydrogenase
(-) dna synthesis
DMARD
methotrexate
current dmard of choice
(-) folate syn (dna syn) by:
inh AICAR transformylase
inh thymidylate synthetase/ dihydrofolate reductase
adr: mucosuppression (rescue: folinic acid/leucovorin)
mycophenolate
inh cytosine monophosphate (CMP)
adr: aplastic anemia
DMARD
sulfasalazine
prodrug
active: sulfapyridine
adr: sjs
DMARD
infliximab
monoclonal antibody
tnf alpha blocker
tnf alpha = signals wbc to attach to joints
DMARD
adalimumab
monoclonal antibody
tnf alpha blocker
tnf alpha = signals wbc to attach to joints
DMARD
etanercept
decoy receptor
tnf alpha blocker
tnf alpha = signals wbc to attach to joints
DMARD
colchicine
500 mcg
inh tubulin (for wbc migration)
short duration (acute gout)
loading dose: 2 tabs
after 2 hrs: 1 tab
every 12 hrs: 1 tab (5-7 days)
antigout
allopurinol
doc for chronic gout
purine analogue
active metabolite: alloxanthine
xanthine oxidase inh
dec uric acid
antigout
febuxostat
first non-purine xanthine oxidase inh
dec uric acid
antigout
probenecid
inh absorption of uric acid in PCT
uricosuric agents
+ penicillin = longer action for penicillin (inh secretion)
sulfapyrazone
inh absorption of uric acid in PCT
uricosuric agents
