Adrenergic/ Sympathetic Flashcards
epinephrine/ adrenaline
DOC for anaphylactic shock
prolongs lidocaine’s duration
inc blood sugar levels
alpha & beta agonist
direct acting adrenergic agonist
sympathetic effect
norepinephrine
DOC for septic shock
greater vasoconstriction than epi (acts more on a receptors)
alpha & beta agonist
direct acting adrenergic agonist
sympathetic effect
dopamine
may be used for shocks (never DOC)
low dose: d receptors (0.5 mcg/kg/min)
moderate dose: b receptors (5-15)
high dose: a receptors (>15-20)
alpha & beta agonist
direct acting adrenergic agonist
sympathetic effect
phenylephrine
use nmt 3 days
watchout for htn px
alpha 1 agonist
direct acting adrenergic agonist
sympathetic effect
phenylpropanolamine
aka pseudoephedrine
Neozep, Sinutab
alpha 1 agonist
direct acting adrenergic agonist
sympathetic effect
methoxamine
alpha 1 agonist
direct acting adrenergic agonist
sympathetic effect
clonidine
oral: px w resistant htn
sublingual: htn crisis
alpha 2 agonist
direct acting adrenergic agonist
parasympathetic effect
methyldopa
allowed for pregnant
(+) coomb’s test
alpha 2 agonist
direct acting adrenergic agonist
parasympathetic effect
guanfacine
alpha 2 agonist
direct acting adrenergic agonist
parasympathetic effect
guanabenz
alpha 2 agonist
direct acting adrenergic agonist
parasympathetic effect
oxymetazoline
effect on a2 not evident
may still cause rebound congestion
alpha 1&2 agonist
direct acting adrenergic agonist
sympathetic effect
dobutamine
DOC for cardiogenic shock
beta 1 agonist
direct acting adrenergic agonist
sympathetic effect
albuterol/salbutamol
short acting beta agonist (SABA)
for asthma
stimulates b1 at high concentration
beta 2 agonist
direct acting adrenergic agonist
sympathetic effect
terbutaline
short acting beta agonist (SABA)
for asthma
stimulates b1 at high concentration
off label: tocolytic
beta 2 agonist
direct acting adrenergic agonist
sympathetic effect
metaproterenol
long acting beta agonist (LABA)
for asthma
stimulates b1 at high concentration
beta 2 agonist
direct acting adrenergic agonist
sympathetic effect
salmeterol
long acting beta agonist (LABA)
for asthma
stimulates b1 at high concentration
beta 2 agonist
direct acting adrenergic agonist
sympathetic effect
formeterol
long acting beta agonist (LABA)
for asthma
stimulates b1 at high concentration
beta 2 agonist
direct acting adrenergic agonist
sympathetic effect
isoproterenol
beta 1&2 agonist
direct acting adrenergic agonist
sympathetic effect
tyramine
from red wine, cheese, beer, chocolate
converted to tyrosine (catecholamines)
can cause htn w MAOI
indirect acting adrenergic agonist
sympathetic effect
methylphenidate
Ritalin
for ADHD, anorexiant, narcolepsy
inc catecholamines release
indirect acting adrenergic agonist
sympathetic effect
amphetamine
for ADHD, anorexiant, narcolepsy
inc catecholamines release
indirect acting adrenergic agonist
sympathetic effect
phentermine
for ADHD, anorexiant, narcolepsy
inc catecholamines release
indirect acting adrenergic agonist
sympathetic effect
ephedrine
alkaloid
mixed (direct & indirect adrenergic agonist)
sympathetic effect
metaraminol
mixed (direct & indirect adrenergic agonist)
sympathetic effect
zosin
S/E: orthostatic hypotension
remedy: adjust first dose to 1/3 or 1/4 of normal dose
alpha 1 blocker
adrenergic antagonist
parasympathetic effect
yohimbine
tx for impotence
alpha 2 blocker
adrenergic antagonist
sympathetic effect
phenoxybenzamine
irreversible & long acting
tx for htn due to pheochromocytoma and raynaud disease
alpha 1&2 blocker (a2 not evident)
adrenergic antagonist
parasympathetic effect
phentolamine
reversible, short acting
pheochromocytoma induced htn
alpha 1&2 blocker (a2 not evident)
adrenergic antagonist
parasympathetic effect
propranolol
prototype
DOC for stage fright
CI: asthma
masks hypoglycemia symptoms (tachycardia, nervousness, tremor)
non selective beta blocker
adrenergic antagonist
paraysmpathetic effect
nadolol
CI: asthma
masks hypoglycemia symptoms (tachycardia, nervousness, tremor)
non selective beta blocker
adrenergic antagonist
paraysmpathetic effect
sotalol
CI: asthma
masks hypoglycemia symptoms (tachycardia, nervousness, tremor)
non selective beta blocker
adrenergic antagonist
paraysmpathetic effect
timolol
dec aqueous humor = tx for glaucoma
CI: asthma
masks hypoglycemia symptoms (tachycardia, nervousness, tremor)
non selective beta blocker
adrenergic antagonist
paraysmpathetic effect
nebivolol
most cardioselective
b1 antagonist
adrenergic antagonist
parasympathetic effect
celiprolol
b1 antagonist
adrenergic antagonist
parasympathetic effect
isoprolol
b1 antagonist
adrenergic antagonist
parasympathetic effect
betaxolol
b1 antagonist
adrenergic antagonist
parasympathetic effect
esmolol
b1 antagonist
adrenergic antagonist
parasympathetic effect
acebutalol
b1 antagonist
adrenergic antagonist
parasympathetic effect
atenolol
b1 antagonist
adrenergic antagonist
parasympathetic effect
metoprolol
b1 antagonist
adrenergic antagonist
parasympathetic effect
acebutalol (2)
lesser hypotension
BB w partial agonist activity
adrenergic antagonist
parasympathetic effect
celiprolol
lesser hypotension
BB w partial agonist activity
adrenergic antagonist
parasympathetic effect
penbutolol
lesser hypotension
BB w partial agonist activity
adrenergic antagonist
parasympathetic effect
pindolol
lesser hypotension
BB w partial agonist activity
adrenergic antagonist
parasympathetic effect
labetalol
lesser hypotension
BB w partial agonist activity
adrenergic antagonist
parasympathetic effect
carteolol
lesser hypotension
BB w partial agonist activity
adrenergic antagonist
parasympathetic effect
combined a and b blockers
labetalol and carvedilol
for htn emergency
ph: nicardipine
fenoldepam
dopamine 1 agonist
direct acting adrenergic agonist
renal vasodilation
