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MOD 4 - Pharmacology > Adrenergic/ Sympathetic > Flashcards

Adrenergic/ Sympathetic Flashcards

1
Q

epinephrine/ adrenaline

A

DOC for anaphylactic shock
prolongs lidocaine’s duration
inc blood sugar levels

alpha & beta agonist
direct acting adrenergic agonist
sympathetic effect

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2
Q

norepinephrine

A

DOC for septic shock
greater vasoconstriction than epi (acts more on a receptors)

alpha & beta agonist
direct acting adrenergic agonist
sympathetic effect

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3
Q

dopamine

A

may be used for shocks (never DOC)

low dose: d receptors (0.5 mcg/kg/min)
moderate dose: b receptors (5-15)
high dose: a receptors (>15-20)

alpha & beta agonist
direct acting adrenergic agonist
sympathetic effect

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4
Q

phenylephrine

A

use nmt 3 days
watchout for htn px

alpha 1 agonist
direct acting adrenergic agonist
sympathetic effect

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5
Q

phenylpropanolamine

A

aka pseudoephedrine
Neozep, Sinutab

alpha 1 agonist
direct acting adrenergic agonist
sympathetic effect

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6
Q

methoxamine

A

alpha 1 agonist
direct acting adrenergic agonist
sympathetic effect

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7
Q

clonidine

A

oral: px w resistant htn
sublingual: htn crisis

alpha 2 agonist
direct acting adrenergic agonist
parasympathetic effect

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8
Q

methyldopa

A

allowed for pregnant
(+) coomb’s test

alpha 2 agonist
direct acting adrenergic agonist
parasympathetic effect

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9
Q

guanfacine

A

alpha 2 agonist
direct acting adrenergic agonist
parasympathetic effect

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10
Q

guanabenz

A

alpha 2 agonist
direct acting adrenergic agonist
parasympathetic effect

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11
Q

oxymetazoline

A

effect on a2 not evident
may still cause rebound congestion

alpha 1&2 agonist
direct acting adrenergic agonist
sympathetic effect

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12
Q

dobutamine

A

DOC for cardiogenic shock

beta 1 agonist
direct acting adrenergic agonist
sympathetic effect

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13
Q

albuterol/salbutamol

A

short acting beta agonist (SABA)
for asthma
stimulates b1 at high concentration

beta 2 agonist
direct acting adrenergic agonist
sympathetic effect

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14
Q

terbutaline

A

short acting beta agonist (SABA)
for asthma
stimulates b1 at high concentration
off label: tocolytic

beta 2 agonist
direct acting adrenergic agonist
sympathetic effect

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15
Q

metaproterenol

A

long acting beta agonist (LABA)
for asthma
stimulates b1 at high concentration

beta 2 agonist
direct acting adrenergic agonist
sympathetic effect

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16
Q

salmeterol

A

long acting beta agonist (LABA)
for asthma
stimulates b1 at high concentration

beta 2 agonist
direct acting adrenergic agonist
sympathetic effect

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17
Q

formeterol

A

long acting beta agonist (LABA)
for asthma
stimulates b1 at high concentration

beta 2 agonist
direct acting adrenergic agonist
sympathetic effect

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18
Q

isoproterenol

A

beta 1&2 agonist
direct acting adrenergic agonist
sympathetic effect

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19
Q

tyramine

A

from red wine, cheese, beer, chocolate
converted to tyrosine (catecholamines)
can cause htn w MAOI

indirect acting adrenergic agonist
sympathetic effect

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20
Q

methylphenidate

A

Ritalin
for ADHD, anorexiant, narcolepsy
inc catecholamines release

indirect acting adrenergic agonist
sympathetic effect

21
Q

amphetamine

A

for ADHD, anorexiant, narcolepsy
inc catecholamines release

indirect acting adrenergic agonist
sympathetic effect

22
Q

phentermine

A

for ADHD, anorexiant, narcolepsy
inc catecholamines release

indirect acting adrenergic agonist
sympathetic effect

23
Q

ephedrine

A

alkaloid
mixed (direct & indirect adrenergic agonist)
sympathetic effect

24
Q

metaraminol

A

mixed (direct & indirect adrenergic agonist)
sympathetic effect

25
Q

zosin

A

S/E: orthostatic hypotension
remedy: adjust first dose to 1/3 or 1/4 of normal dose

alpha 1 blocker
adrenergic antagonist
parasympathetic effect

26
Q

yohimbine

A

tx for impotence

alpha 2 blocker
adrenergic antagonist
sympathetic effect

27
Q

phenoxybenzamine

A

irreversible & long acting
tx for htn due to pheochromocytoma and raynaud disease

alpha 1&2 blocker (a2 not evident)
adrenergic antagonist
parasympathetic effect

28
Q

phentolamine

A

reversible, short acting
pheochromocytoma induced htn

alpha 1&2 blocker (a2 not evident)
adrenergic antagonist
parasympathetic effect

29
Q

propranolol

A

prototype
DOC for stage fright
CI: asthma
masks hypoglycemia symptoms (tachycardia, nervousness, tremor)

non selective beta blocker
adrenergic antagonist
paraysmpathetic effect

30
Q

nadolol

A

CI: asthma
masks hypoglycemia symptoms (tachycardia, nervousness, tremor)

non selective beta blocker
adrenergic antagonist
paraysmpathetic effect

31
Q

sotalol

A

CI: asthma
masks hypoglycemia symptoms (tachycardia, nervousness, tremor)

non selective beta blocker
adrenergic antagonist
paraysmpathetic effect

32
Q

timolol

A

dec aqueous humor = tx for glaucoma
CI: asthma
masks hypoglycemia symptoms (tachycardia, nervousness, tremor)

non selective beta blocker
adrenergic antagonist
paraysmpathetic effect

33
Q

nebivolol

A

most cardioselective
b1 antagonist
adrenergic antagonist
parasympathetic effect

34
Q

celiprolol

A

b1 antagonist
adrenergic antagonist
parasympathetic effect

35
Q

isoprolol

A

b1 antagonist
adrenergic antagonist
parasympathetic effect

36
Q

betaxolol

A

b1 antagonist
adrenergic antagonist
parasympathetic effect

37
Q

esmolol

A

b1 antagonist
adrenergic antagonist
parasympathetic effect

38
Q

acebutalol

A

b1 antagonist
adrenergic antagonist
parasympathetic effect

39
Q

atenolol

A

b1 antagonist
adrenergic antagonist
parasympathetic effect

40
Q

metoprolol

A

b1 antagonist
adrenergic antagonist
parasympathetic effect

41
Q

acebutalol (2)

A

lesser hypotension

BB w partial agonist activity
adrenergic antagonist
parasympathetic effect

42
Q

celiprolol

A

lesser hypotension

BB w partial agonist activity
adrenergic antagonist
parasympathetic effect

43
Q

penbutolol

A

lesser hypotension

BB w partial agonist activity
adrenergic antagonist
parasympathetic effect

44
Q

pindolol

A

lesser hypotension

BB w partial agonist activity
adrenergic antagonist
parasympathetic effect

45
Q

labetalol

A

lesser hypotension

BB w partial agonist activity
adrenergic antagonist
parasympathetic effect

46
Q

carteolol

A

lesser hypotension

BB w partial agonist activity
adrenergic antagonist
parasympathetic effect

47
Q

combined a and b blockers

A

labetalol and carvedilol
for htn emergency

ph: nicardipine

48
Q

fenoldepam

A

dopamine 1 agonist
direct acting adrenergic agonist
renal vasodilation

MOD 4 - Pharmacology (19 decks)

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