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MOD 4 - Pharmacology > CNS Drugs - Antiseizure > Flashcards

CNS Drugs - Antiseizure Flashcards

1
Q

stiff muscles
jerking movements

A

general tonic clonic
aka grand mal
all neurons firing
loss of consciousness

generalized seizure

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2
Q

blank stare
usually in pedia patients

A

abscence seizure
aka petit mal
all neurons firing
loss of consciousness

generalized seizure

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3
Q

focal-onset seizure
no loss of consciousness

A

simple partial

partial seizure

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4
Q

focal-onset seizure
w/ loss of consciousness

A

complex partial

partial seizure

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5
Q

Cl influx

A

hyperpolarize membrane = no action potential

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6
Q

dec Na, Ca influx

A

delay depolarization/prolong repolarization

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7
Q

diazepam

A

Valium
long acting

benzodiazepine
inc frequency of Cl channel opening

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8
Q

midazolam

A

Versed; Dormicum
short acting

benzodiazepine
inc frequency of Cl channel opening

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9
Q

alprazolam

A

Xanax

benzodiazepine
inc frequency of Cl channel opening

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10
Q

lorazepam

A

Ativan

benzodiazepine
inc frequency of Cl channel opening

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11
Q

triazolam

A

Halcion

benzodiazepine
inc frequency of Cl channel opening

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12
Q

zolpidem

A

Ambien
hypnotic

non-benzo benzodiazepine
(same structure as bnz w/out anti-seizure activity)

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13
Q

buspirone

A

BusPar
anxiolytic

non-benzo benzodiazepine
(same structure as bnz w/out anti-seizure activity)

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14
Q

thiopental

A

Pentothal
anesthesia
induction of anesthesia

ultra short acting
barbiturates
inc duration of Cl channel opening

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15
Q

amobarbital

A

insomnia

short acting
barbiturates
inc duration of Cl channel opening

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16
Q

pentobarbital

A

insomnia

short acting
barbiturates
inc duration of Cl channel opening

17
Q

secobarbital

A

Seconal

insomnia

short acting
barbiturates
inc duration of Cl channel opening

18
Q

phenobarbital

A

Luminal

seizures

long acting
barbiturates
inc duration of Cl channel opening

19
Q

DOC for simple partial

A

carbamazepine

20
Q

DOC for complex partial

A

carbamazepine

21
Q

DOC for tonic clonic

A

valproic acid

22
Q

DOC for abscence

A

ethosuximide

23
Q

DOC for myoclonic

A

valproic acid

24
Q

DOC for atonic

A

valproic acid

25
Q

DOC for febrile seizure

A

phenobarbital
diazepam

26
Q

DOC for status epilepticus

A

diazepam (old)
lorazepam (new)
phenobarbital
phenytoin

27
Q

tonic clonic seizure

A

carbamazepine (Na -)
lamotrigine (NaK -)
phenytoin (Na -)
valproic acid (Na - & inc K efflux)

28
Q

absence seizure

A

clonazepam (Rivotril)
ethosuximide
valproic acid

29
Q

myoclonic seizure

A

clonazepam
lamotrigine
valproic acid

30
Q

inhibits binding to synaptic vesicular protein 2A (SV2A)

A

levetiracetam

31
Q

back-up & adjunct drug

A

felbamate
gabapentin (DOC for neuropathic pain)
lamotrigine
levetiracetam
phenobarbital
tiagabine
topiramate
vigabatrin
zonisamide

MOD 4 - Pharmacology (19 decks)

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