CNS Drugs - Antiseizure Flashcards by rph soon

Q

stiff muscles
jerking movements

A

general tonic clonic
aka grand mal
all neurons firing
loss of consciousness

generalized seizure

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Q

blank stare
usually in pedia patients

A

abscence seizure
aka petit mal
all neurons firing
loss of consciousness

generalized seizure

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Q

focal-onset seizure
no loss of consciousness

A

simple partial

partial seizure

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Q

focal-onset seizure
w/ loss of consciousness

A

complex partial

partial seizure

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Q

Cl influx

A

hyperpolarize membrane = no action potential

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Q

dec Na, Ca influx

A

delay depolarization/prolong repolarization

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Q

diazepam

A

Valium
long acting

benzodiazepine
inc frequency of Cl channel opening

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Q

midazolam

A

Versed; Dormicum
short acting

benzodiazepine
inc frequency of Cl channel opening

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Q

alprazolam

A

Xanax

benzodiazepine
inc frequency of Cl channel opening

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Q

lorazepam

A

Ativan

benzodiazepine
inc frequency of Cl channel opening

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Q

triazolam

A

Halcion

benzodiazepine
inc frequency of Cl channel opening

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Q

zolpidem

A

Ambien
hypnotic

non-benzo benzodiazepine
(same structure as bnz w/out anti-seizure activity)

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Q

buspirone

A

BusPar
anxiolytic

non-benzo benzodiazepine
(same structure as bnz w/out anti-seizure activity)

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Q

thiopental

A

Pentothal
anesthesia
induction of anesthesia

ultra short acting
barbiturates
inc duration of Cl channel opening

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Q

amobarbital

A

insomnia

short acting
barbiturates
inc duration of Cl channel opening

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Q

pentobarbital

A

insomnia

short acting
barbiturates
inc duration of Cl channel opening

Q

secobarbital

A

Seconal

insomnia

short acting
barbiturates
inc duration of Cl channel opening

Q

phenobarbital

A

Luminal

seizures

long acting
barbiturates
inc duration of Cl channel opening

Q

DOC for simple partial

A

carbamazepine

Q

DOC for complex partial

A

carbamazepine

Q

DOC for tonic clonic

A

valproic acid

Q

DOC for abscence

A

ethosuximide

Q

DOC for myoclonic

A

valproic acid

Q

DOC for atonic

A

valproic acid

DOC for febrile seizure

phenobarbital diazepam

DOC for status epilepticus

diazepam (old) lorazepam (new) phenobarbital phenytoin

tonic clonic seizure

carbamazepine (Na -) lamotrigine (NaK -) phenytoin (Na -) valproic acid (Na - & inc K efflux)

absence seizure

clonazepam (Rivotril) ethosuximide valproic acid

myoclonic seizure

clonazepam lamotrigine valproic acid

inhibits binding to synaptic vesicular protein 2A (SV2A)

levetiracetam

back-up & adjunct drug

felbamate gabapentin (DOC for neuropathic pain) lamotrigine levetiracetam phenobarbital tiagabine topiramate vigabatrin zonisamide