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MOD 4 - Pharmacology > Cholinergic/ Parasympathetic > Flashcards

Cholinergic/ Parasympathetic Flashcards

1
Q

Acetylcholine

A

prototype

choline esters
direct acting cholinergic agonists
paraysmpathetic effect

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2
Q

bethanechol

A

not hydrolyzed by AChE

choline esters
direct acting cholinergic agonists
paraysmpathetic effect

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3
Q

carbachol

A

not hydrolyzed by AChE

choline esters
direct acting cholinergic agonists
paraysmpathetic effect

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4
Q

methacholine

A

tx for asthma before

choline esters
direct acting cholinergic agonists
paraysmpathetic effect

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5
Q

pilocarpine

A

DOC for emergency lowering of intraoccular pressure

alkaloid
direct acting cholinergic agonists
paraysmpathetic effect

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6
Q

arecoline

A

alkaloid
direct acting cholinergic agonists
paraysmpathetic effect

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7
Q

muscarine

A

from mushrooms

alkaloid
direct acting cholinergic agonists
paraysmpathetic effect

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8
Q

edrophonium

A

Tensilon
prototype
dx for myasthenia gravis

quaternary amine - short duration
indirect acting cholinergic agonist
parasympathetic effect

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9
Q

physostigmine

A

antidote for anti-ACh poisoning (atropine, phenothiazene, TCA)

carbamates - intermediate duration
indirect acting cholinergic agonist
parasympathetic effect

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10
Q

neostigmine

A

antidote for tubocurarine poisoning

carbamates - intermediate duration
indirect acting cholinergic agonist
parasympathetic effect

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11
Q

pyridostigmine

A

Mestinon

carbamates - intermediate duration
indirect acting cholinergic agonist
parasympathetic effect

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12
Q

carbamate insecticides

A

carbacyl, methylcarbamate

carbamates - intermediate duration
indirect acting cholinergic agonist
parasympathetic effect

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13
Q

isoflurophate

A

tx for glaucoma

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

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14
Q

echothiphate

A

tx for glaucoma

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

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15
Q

malathion

A

pesticide

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

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16
Q

parathion

A

pesticide

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

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17
Q

tabun

A

chemical warfare

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

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18
Q

sarin

A

chemical warfare

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

19
Q

soman

A

chemical warfare

lipid soluble organophosphates - long duration
indirect acting cholinergic agonist
parasympathetic effect

20
Q

atropine

A

prototype
active isomer: L-hyoscyamine

muscarinic blocker
cholinergic antagonist
sympathetic effect

21
Q

scopolamine

A

aka hyoscine
Buscopan
CI: pregnancy

muscarinic blocker
cholinergic antagonist
sympathetic effect

22
Q

homatropine

A

muscarinic blocker
cholinergic antagonist
sympathetic effect

23
Q

cyclopentolate

A

muscarinic blocker
cholinergic antagonist
sympathetic effect

24
Q

tropicamide

A

muscarinic blocker
cholinergic antagonist
sympathetic effect

25
Q

ipratropium

A

muscarinic blocker (M3 lungs)
cholinergic antagonist
sympathetic effect

26
Q

tiotropium

A

muscarinic blocker (M3 lungs)
cholinergic antagonist
sympathetic effect

27
Q

pirenprizine

A

tx for peptic ulcer

muscarinic blocker
cholinergic antagonist
sympathetic effect

28
Q

benztropine

A

tx for parkinsons

muscarinic blocker
cholinergic antagonist
sympathetic effect

29
Q

trihexyphenidyl

A

tx for parkinsons

muscarinic blocker
cholinergic antagonist
sympathetic effect

30
Q

biperiden

A

tx for parkinsons

muscarinic blocker
cholinergic antagonist
sympathetic effect

31
Q

darifenacin

A

tx for overactive bladder

muscarinic blocker
cholinergic antagonist
sympathetic effect

32
Q

fesoterodine

A

tx for overactive bladder

muscarinic blocker
cholinergic antagonist
sympathetic effect

33
Q

oxybutynin

A

tx for overactive bladder

muscarinic blocker
cholinergic antagonist
sympathetic effect

34
Q

solifenacin

A

tx for overactive bladder

muscarinic blocker
cholinergic antagonist
sympathetic effect

35
Q

tolterodine

A

tx for overactive bladder

muscarinic blocker
cholinergic antagonist
sympathetic effect

36
Q

trospium chloride

A

tx for overactive bladder

muscarinic blocker
cholinergic antagonist
sympathetic effect

37
Q

other muscarinic blockers:

A

antihistamines, antipsychotics, TCA

tx for overactive bladder

muscarinic blocker
cholinergic antagonist
sympathetic effect

38
Q

nicotine

A

stimulate then block

ganglionic blocker
cholinergic antagonist
sympathetic effect

39
Q

hexamethonium

A

block w/out prior stimulation

ganglionic blocker
cholinergic antagonist
sympathetic effect

40
Q

mecamylamine

A

block w/out prior stimulation

ganglionic blocker
cholinergic antagonist
sympathetic effect

41
Q

trimethaphan

A

block w/out prior stimulation

ganglionic blocker
cholinergic antagonist
sympathetic effect

42
Q

lobeline

A

ganglionic blocker
cholinergic antagonist
sympathetic effect

43
Q

tubocurarine

A

isoquinoline: atracurium, tubocurarine
steroidal: pancuronium, rocuronium

low dose: competitive block receptor
high dose: block ion channel

non depolarizing, competitive, reversible
neuromuscular blocker
cholinergic antagonist
sympathetic effect

44
Q

succinylcholine

A

contract then rest

depolarizing, irreversible, non-competitive
neuromuscular blocker
cholinergic antagonist
sympathetic effect

MOD 4 - Pharmacology (19 decks)

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