Cumulative Exam Part 4 Flashcards
Striated, voluntary, large in size, multinucleated
Skeletal muscle
How is skeletal muscle attached to bone?
Tendons
Functions to move or stabilize skeleton, generate heat, voluntary sphincters
Skeletal muscle
Striated but involuntary, intercalated discs, circulates blood and audtorhythmicity
Cardiac muscle
Non-striated, involuntary, spindle shaped, controls diameter of passageways, moves food, urine, reproductive tract secretions
Smooth muscle
Where is smooth muscle found?
Around blood vessels and in walls of hollow organs
What are the 5 functions of muscles?
Body movement, stabilize body position, store and move substances in body, heat production, store nutrients
Cell membrane of muscle
Sarcolemma
Surrounds each myofibril; stores and releases calcium for muscle contraction
Sarcoplasmic reticulum
Network of tubules used to convey electrical impulses for muscle contraction, allows muscle fiber to contract simultaneously
T-tubules
Refers to a wasting of muscle due to the loss of myofibrils within muscle fibers
Muscular atrophy
Increase in size of muscle fiber due to increased production of myofibrils
Muscular hypertrophy
What is the organization of muscle from superficial to deep? (10)
Epimysium, whole muscle, perimysium, fascicle, endomysium, sarcolemma, muscle fiber, sarcoplasmic reticulum, myofibril, myofilament
Striped or striated pattern within myofibrils; alternating dark thick filaments and thin filaments
Striations
What is the 1st step in the sliding filament theory?
AP leads to release of Ca by sarcoplasmic reticulum, Ca binds to troponin causing the active sites on actin to be exposed
What is the 2nd step in the sliding filament theory?
Cross bridges form when myosin heads bind onto actin
What is the 3rd step in the sliding filament theory?
Myosin heads pivot towards the M line
What is the 4th step in the sliding filament theory?
ATP gives myosin heads energy to unattached and reset
Time period of muscle rigidity following death, due to depletion of ATP
Rigor mortis
Synapse between motor neuron and skeletal muscle fiber
Neuromuscular junction
Site of communication between somatic motor neuron and skeletal muscle fiber of another cell
Synapse
How many NMJ’s does each muscle fiber have?
1
What is the presynaptic cell in an NMJ?
Axon
What is the postsynaptic cell in an NMJ?
Muscle cells
Expanded tip of the axon at NMJ
Synaptic terminal
Vesicle filled with neurotransmitters
Synaptic vesicle
Space that separates synaptic terminal from motor end plate
Synaptic cleft
What is the 1st step of physiology at NMJ?
Action potential travels down axon to synaptic terminal
What is the 2nd step of physiology at NMJ?
Calcium channels open which causes the exocytosis of synaptic vesicles filled with acetylcholine
What is the 3rd step of physiology at NMJ?
ACh diffuses in to synaptic cleft and binds onto the surface of sarcolemma at the motor end plate, sodium rushes into sarcoplasm
What is the 4th step of physiology at NMJ?
Rush of sodium causes an action potential in the sarcolemma starting the muscle contraction
Enzyme that breaks down ACh
Acetylcholinesterase