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MBBS CPRS > CPRS 62: Cholesterol, the good, the balance and the bad > Flashcards

CPRS 62: Cholesterol, the good, the balance and the bad Flashcards

1
Q

Is cholesterol hydrophobic or hydrophilic

A

Hydrophobic

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2
Q

Arrange the hydrophobicity of the following 2 stuff, descending order
Free cholesterol
Cholesterol ester

A

Cholesterol Ester > Free Cholesterol

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3
Q

Usually, dietary cholesterol contains _____% free cholesterol and ______% cholesterol ester

A

85-90% free cholesterol and 10-15% cholesterol ester

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4
Q

what is the enzyme converting cholesterol ester to free cholesterol

A

Cholesterol ester hydrolase

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5
Q

What is the organ centre for dealing with cholesterol uptake, removal, synthesis, conversion

A

Liver

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6
Q

What drug can block cholesterol absorption

A

Ezetimib

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7
Q

Name 4 compounds involved in the De Novo Cholesterol Synthesis

A 
Acetyl-CoA
HMG-CoA
Mevalonic Acid
Cholesterol
(In order of compound conversion)
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8
Q

What is the enzyme related to the conversion of the compounds in De Novo Cholesterol Synthesis?

A

HMG CoA Reductase

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9
Q

What compound reaction does HMG CoA Reductase limit

A

HMG-CoA to Mevalonic Acid

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10
Q

What compounds favour HMG CoA Reductase

A

Insulin

Thyroxin

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11
Q

What compounds suppress HMG CoA Reductase

A

Glucagon

Glucocorticoids

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12
Q

What compounds does De Novo Cholesterol Synthesis consume?

A

ATP

NADPH

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13
Q

What is the pKa of -COOH group

And where is 50% of the bile acids deprotonated?

A

pKa=6

Duodenum

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14
Q

What can cholesterol further conjugate with to further reduce the pKa

A

Taurine

Glycine

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15
Q

Bile Acid synthesis in the liver: What is made from cholesterol?

A 
Chenodeoxycholic Acid (Diol)
Cholic Acid (Triol)
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16
Q

What drug can be used to treat cholesterolemia?

A

Cholestyramine

17
Q

Cholesterol is the precursor for _________ and _______.

A

Vitamin D3

Bile Acids

18
Q

What is involved in the reverse cholesterol transport from the other cells to the liver

A

HDL

19
Q

What will result if too much cholesterol is accumulated in the body

A

Atherosclerosis

20
Q

Lp (a) differs from LDL by having an extra _______ layer

A

Apo-A

MBBS CPRS (44 decks)

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