CPRS 33: Capillaries and Lymphatics Flashcards
In the capillary wall, there are intercellular clefts. It allows H2O and small molecules to pass, they are smaller than the diameter of ____.
In the capillary wall, there are intercellular clefts. It allows H2O and small molecules to pass, they are smaller than the diameter of ALBUMIN
There are caveolae in the capillaries
What do they do?
Facilitates the transport of macromolecules by transcytosis
Mix and match:
Brain, Kidney, Liver
Continuous, Fenestrated, Discontinuous
Brain- Continuous capillary
Kidney- Fenestrated capillary
Liver- Discontinuous capillary
The large molecules do not pass through the capillary wall, except in the _________ (organ)
except in the liver
Name 2 major components of the interstitial fluid
Proteoglycan filaments
Collagen bundles
Lymph flow
Reabsorption
Filtration
Arrange them such that they make sense in mathematics
Filtration = Reabsorption + Lymph Flow
Otherwise there’ll be accumulation of interstitial fluid
Name the Starling Forces
__________: Forcing plasma from the capillary to interstitium
___________: Forcing H2O from interstitium to the capillary
___________: Cause osmosis from the interstitium to capillary
__________: Cause osmosis from the capillary to the interstitium
Which of the above two are main forces that are ‘useful’?
Name the Starling Forces
Capillary Hydrostatic Pressure: Forcing plasma from the capillary to interstitium
Interstitial Fluid Hydroststic Pressure : Forcing H2O from interstitium to the capillary
Plasma Colloid Osmotic Pressure: Cause osmosis from the interstitium to capillary
Interstitial Fluid Colloid Osmotic Pressure: Cause osmosis from the capillary to the interstitium
Which of the above two are main forces that are ‘useful’?
Capillary Hydrostatic Pressure
Plasma Colloid Osmotic Pressure
Pressure in interstitial fluid can be increased by wearing __________ in lower limbs
Colloid Osmotic Pressure are exerted by _______ that don’t pass through the _________
Inflammation makes the capillaries ______ (more or less) permeable to proteins
Pressure in interstitial fluid can be increased by wearing compression stockings in lower limbs
Colloid Osmotic Pressure are exerted by proteins that don’t pass through the capillary wall
Inflammation makes the capillaries MORE permeable to proteins
Net Fluid Flux is proportional to
Capillary Hydrostatic Pressure
+ Interstitial Fluid Colloid Osmotic Pressure
- Plasma Colloid Osmotic Pressure
- Interstitial Fluid Hydrostatic Pressure
If net fluid flux is positive, there is net fluid movement ____ (in or out) of the capillaries.
If net fluid flux is negative, there is net fluid movement ____ (in or out) of the capillaries.
Net Fluid Flux is proportional to
Capillary Hydrostatic Pressure
+ Interstitial Fluid Colloid Osmotic Pressure
- Plasma Colloid Osmotic Pressure
- Interstitial Fluid Hydrostatic Pressure
If net fluid flux is positive, there is net fluid movement OUT of the capillaries.
If net fluid flux is negative, there is net fluid movement INTO the capillaries.
Lymphatic Capillary has ______ valves. They are one way valves and allows content to move in once the pressure of ___________ is larger than that of the ________.
Lymphatic vessels has _______ valves, they restrict the ________ of the lymph. There are also __________ around the lymph vessels that pushs the lymph forward by contraction.
The lymph vessels ultimately drain to the _________ veins.
Lymphatic Capillary has primary valves. They are one way valves and allows content to move in once the pressure of interstitial fluid is larger than that of the lymph.
Lymphatic vessels has secondary valves, they restrict the backflow of the lymph. There are also smooth muscles around the lymph vessels that pushs the lymph forward by contraction.
The lymph vessels ultimately drain to the subclavian veins.
Name 2 more factors that drive the lymph flow
Contraction of surrounding skeletal muscles
Pulsations of arteries adjacent to the lymph
Compression stocking
How will heart failure lead to oedema
Reduce cardiac output Reduce venous return Increase \_\_\_\_\_\_\_\_\_\_\_\_ (one of Starling forces) Increase filtration Accumulation of \_\_\_\_\_\_\_\_\_\_\_\_\_\_ Oedema
How will heart failure lead to oedema
Reduce cardiac output Reduce venous return Increase capillary hydrostatic pressure Increase filtration Accumulation of interstitial fluid Oedema
How will malnutrition (low protein) or Proteinuria lead to oedema
Reduce plasma protein Reduce \_\_\_\_\_\_\_\_\_\_\_\_\_\_ (one of Starling forces) Reduce capillary \_\_\_\_\_\_\_\_\_\_\_ Accumulation of \_\_\_\_\_\_\_\_\_\_\_\_ Oedema
How will malnutrition (low protein) or Proteinuria lead to oedema
Reduce plasma protein Reduce Plasma colloid osmotic pressure Reduce capillary reabsorption Accumulation of interstitial fluid Oedema
