Chpt 13 (14) - Lymph & Immune System Flashcards
Lymphatic System: Functions
- Reduces tissue edema (swelling)
- Returns proteins from interstitial fluid back to blood
- Traps and Filters cellular debris and foreign substance; bacteria, toxins, cancer cells, viruses, pathogens
- Recycles body fluid
- Circulates lymphocytes to assist with immune function
- Transports fats from GI tract back to blood stream
Immune System: Functions
- Protects the body from foreign invasion
- Coordinates activities in the blood stream, tissues, and lymph to protect body from invasion
- Fights infection and protects against future infections by producing antibodies and immune cells
- Production of immunoglobulin (Antibodies)
Lymphatic System
1 way “drainage” of tissue plasma back to heart to lower edema (swelling) of body’s tissue
Afferent Lymphatic Vessels
Bring fluid into lymph nodes
Efferent Lymphatic Vessels
Allow fluid to leave lymph nodes
Germinal Centers (follicle)
“Filter” sites within lymph nodes which contain macrophages to filter fluid
Hilus
Area of lymph node where efferent vessels exit
Medulla
Center of lymph node
Capsule
Outer shell of lymph node
Papilteal
Region around knee containing lymph nodes
Inguinal and Femoral
Region around groin and femur point which contains lymph nodes
Mesenteric
RLQ, above Inguinal which contains lymph nodes
Spleenic
LUQ, spleen as a lymph node
Mediastinal
Region in middle of chest which contains lymph nodes
Axillary
Region near armpits which contain lymph nodes
Infraclavicular
Region near clavicle which contains lymph nodes
Cervical
Region around throat which contains lymph nodes
Hilar
Region near heart that contains lymph nodes
Lymph Pathways
Vessels that transport lymph fluid
- Lymph capillaries - Receive fluid and debris - Moves one way, toward heart - Valves encourage one way flow
Lymph Nodes
- Located near joints
- Filter foreign substances
- Primary Filtering agents:
- Macrophages
- Lymphocytes
No lymph nodes in CNS
Spleen
- Largest lymph organ
- LUQ of abdomen
- Removes: Bacteria, Old RBCs
- Filters Blood
- Produces antibodies
Cells of Immune System
Stem Cells produce:
- Lymphoid - Myeloid
- Lymphoid produce:
- Lymphocytes
- B Cells
- T Cells
- Lymphocytes
- Myeloid produce:
- Granulocytes
- Neutrophils
- Eosinophils
- Basophils
- Granulocytes
Lymph and Immune Systems
- Share same structure and function roles
- Both Contain:
- Spleen
- Lymph Nodes
- Thymus
- Immune Cells (Leukocytes)
B Cells
Secrete Antibodies
Cytotoxic T Cells
Engulf and kill cancer and infected cells
Helper T Cells (T4)
Activate B Cells and Cytotoxic T Cells
- Affected by HIV
From Leukocytes
Neutrophils - Phagocytes
Basophils - Inflammation
Eosinophils - Parasite Infection
Lymphocytes - Specific Immune Response
Neutrophils
Engulf bacteria and cellular debris; Frontline of immunity
- Myeloid
Lymphocytes
Produce Antibodies and regulate immune response (B & T Cells)
- Specific Immunity
Monocytes
Associated with engulfing cellular debris, antigen processing
Eosinophils
Associated with parasitic infection and allergic response
- Myeloid
Basophils
Associated with hypersensitivity and release histamine
Helper T Cells
Used to activate B Cells to release antibodies to go fight pathogen
Defense Against Pathogen
Pathogen: Disease producing agent
Mechanical & Chemical Defenses:
- Skin; Mucus Membranes, Cilia - Gastric Juices
Natural Immunity:
- Natural resistance to certain disease
Acquired Immunity:
- Exposure to pathogen or vaccination - Humoral and Cell Mediated
Humoral Immunity
B cells which become plasma cells:
- Secrete immunoglobulin (antibodies) - IgG: Bacteria, virus, toxins activate this antibody - IgA: In breast milk, tears, nasal fluid, saliva, gastric juice - IgM: Bacteria, virus' activate this antibody first - IgE: Important in Allergic Reaction
Cell Mediated Immunity (T Cells)
- Acquired active immunity: by T Cell action
- T Cells specific to antigen
- Reproduce and secrete cytokines / lymphokines
- T Cells also activate B cells which secrete antibodies
- Helper T Cells: T4 that stimulate immune response
- Cytotoxic T Cells: T8 destroy infected cells
Aden (o)
Gland
Immun (o)
Immunity
Lymph (o)
Lymph
Lymphaden (o)
Lymph Nodes
Lymphangi (o)
Lymphatic Vessels
Splen (o)
Spleen
Thym (o)
Thymus
Tox (o); Toxic (o); Toxi
Poison
ALL
Acute Lymphocytic Leukemia
AML
Acute Myelogenous Leukemia
CLL
Chronic Lymphocytic Leukemia
CML
Chronic Myelogenous Leukemia
CMV
Cytomegalo Virus
PCP
Pneumocystis Carinii Pneumonia
- EBV *
Epstein-Barr Virus
HSV
Herpes Simplex Virus
Hodgkin’s Lymphoma
Lymph cancer usually appears in early adulthood
Non-Hodgkin’s
Lymph cancer with some healthy cells and spreading in diffusive pattern; appears in middle or older age
Hypersplenism
Overactive enlarged spleen
Anaphylaxis
Life-threatening allergic reaction
Mononucleosis
EBV infection
Splenomegaly
Enlarged spleen
Thymoma
Tumor of thymus gland
Sarcoidosis
Inflammatory condition with lesions involving the lymph nodes, lungs, and other organs
Lymphadenectomy
Removal of lymph node
Lymphadenotomy
Incision into a lymph node
Splenectomy
Removal of spleen
Thymectomy
Removal of thymus gland