Chapter 12 (8) - Blood System Flashcards
Blood
Composed of water, cells, electrolytes, proteins, and nutrients.
Transport Medium - Glucose, hormones, oxygen and waste
5 Liters in body average
Structure and Function of Blood
- Complex mixture of cells, water, proteins and sugars.
- Transports nutrients, oxygen and hormones all over body
- Helps regulate body temperature
- Maintain stability of body’s fluid volume
- Transports waste products away from body cells.
Plasma
Fluid portion (55% of total blood volume)
- Water, Proteins, Electrolytes, Nutrients, Vitamins and Hormones
Cells
Particulate portion (45% total blood volume)
- RBC, WBC, Platelets
Buffy Coat
WBC & Platelets; When centrifuged it is the portion of blood between the plasma above and RBC’s below.
Coagulation
- Blood clotting
- Fibrinogen and Prothrombin are proteins necessary for clotting to occur
- Starts with platelets (temporary plug)
Plasmapheresis
Centrifuge blood which separates plasma from cells and only return cells to patient
Gamma Globulins
Globulin protein fraction
- Immune function (antibodies)
Electrophoresis
Process of separating Globulins into fractions (Alpha, Beta, Gamma, Delta)
- Current applied to globulin proteins from plasma division into subtypes
Red Blood Cells (Erythrocytes)
Live for 120 days; No nucleus to carry more O2
- Produced in Bone Marrow in response to Erythropoietin (Hormone)
- Hemoglobin is a protein in red blood cells that is essential to the transport of oxygen
Hematocrit
Measure of concentration of RBC in blood; should be around 40%ish
Leukocytes
White blood cells, destroy foreign substances
- 2 Main Groups: Granulocytes & Agranulocytes
Granulocytes
- Neutrophils (50%-60%)
- Eosinophils
- Basophils
Agranulocytes
- Monocytes
- Lymphocytes
Neutrophils
50% - 60%, phagocytes of bacteria and viruses
Eosinophils
2% - 3%, Kill parasites, allergic reactions
Basophils
1%, Secrete heparin and histamine (Allergy)
Monocytes
3%
Lymphocytes
25%
Platelets
aka Thrombocytes, live about 10 days
- Assist in blood clotting, control bleeding temporarily
- Derived from Megakaryocytes
Blood Typing
Transfusions of blood rarely worked until the “typing” of blood was developed.
Tested for type to prevent agglutination of clumping of blood cells (transfusion reaction)
4 Types of Blood
Based on which Antigen (Ag) is present in RBC
- Type O: No Antigens Present (Both Antibodies)
- Type A: “A” Antigen present (“B” antibodies)
- Type B: “B” Antigen present (“A” antibodies)
- Type AB: “A & B” Antigen present (No Antibodies
Type O is universal donor.
Type AB is universal recipient
Rh
Type of antigen first discovered in Rhesus monkeys
- ”+” = presence of Rh antigen
- ”-“ = no Rh antigen
WRT Pregnancy
Rh negative mother with Rh positive baby (because of the father) may develop antibodies to attack blood of 2nd pregnancy Rh positive Baby.
Agglutin (o)
Agglutinin
Eosin (o)
Eosinophil
Erythr (o)
Red
Hemat (o)
Blood
Leuk (o)
White
Phag (o)
Eating, Devouring
Thromb (o)
Blood Clot
APTT
Activated Partial Thromboplastin Time
baso
basophil
BCP
Biochemistry Panel
BMT
Bone Marrow Transplant
CBC
Complete Blood Count
dif
Differential Blood Count
eos
Eosinophils
ESR
Erythrocyte Sedimentation Rate
G-CSF
Granulocyte Colony-stimulating Factor
HCT
Hematocrit
HGB
Hemoglobin
MCH
Mean Corpuscular Hemoglobin
MCHC
Mean Corpuscular Hemoglobin Concentration
MCV
Mean Corpuscular Volume
mono
Monocyte
PCV
Packed Cell Volume
PLT
Platelet Count
PMN
Polymorphonuclear Neutrophil
PT
Prothrombin Time
PTT
Partial Thromboplastin Time
RBC
Red Blood Cell
SR
Sedimentation Rate
seg
Segmented Mature White Blood Cell
WBC
White Blood Cell
Venapuncture / Phlebotomy
Withdrawal of blood for examination
Complete Blood Count (CBC)
Common Screen for Hematocrit
Blood Indices
Measurement of size, volume, and content of RBC
Hematocrit
Measures packed red blood cells in a sample
Erythrocyte Sedimentation Rate / Sedimentation Rate
Test for rate at which red blood cells fall through plasma
Antiglobulin Test
Test for antibodies on red blood cells
Blood Chemistry
Test plasma for various substances such as glucose and electrolytes
WBC Differential
Looks at number and type of leukocytes
Hemoglobin
Measures level of Hemoglobin in blood
Prothrombin Time (PT)
Test for coagulation defects
Dyscrasia
General term for any disease of the blood with abnormal material present
Anemia
General term for condition where RBC do not transport enough oxygen to the tissues
- Causes may be related to low number of cells or due to a low amount of hemoglobin
Common Types of Anemia
- Iron Deficiency
- Aplastic
- Pernicious
- Sickle Cell
- Hemolytic
- Posthemorrhagic
Hemophilia
Hereditary disorder in which there is a lack of clotting factor VIII
- Treated with medications & Blood Transfusions
Thrombocytopenia
Bleeding disorder with a lack of platelets
- Occurs in the condition called purpura, which is the presence of multiple tiny hemorrhages under skin
Pancytopenia
Low number of all blood cells
Hemochromatosis
Hereditary disorder that causes excessive iron to build up in the blood
Erythropenia
Low number of RBC
Poikilocytosis
Irregularly shaped red blood cells
Reticulocytosis
Abnormal number of immature RBC
Hemolysis
Breakdown in RBC membrane
Macrocytosis
Abnormally large RBC
Polycythemia
Abnormal increase in RBCs and Hemoglobin
Leukemia
Neoplastic disorder in which there is an excessive increase in WBC
Granulocytosis
Abnormal increase of granulocytes in the bloodstream, commonly seen during times of infection
Multiple Myeloma
Malignant tumor of bone marrow
Bone Marrow Biopsy
Needle inserted into the bone marrow cavity and bone marrow is removed for analysis
Albumin
Protein in Blood
Coagulation
Changing of a liquid (blood) into semi-solid
Erythropoietin
Hormone released by kidneys which stimulate RBC production
Serum
Liquid left after blood has clotted or after clotting factors are removed
SMA
Synonymous with Blood Chemistry
Anemia
Low RBC count or low Hematocrit
Anisocytosis
Condition of abnormal variation in the size of RBC
Hemolysis
Disorder of breakdown of RBC
- Lysis or rupture of erythrocytes
Macrocytosis
Abnormally large cell; specifically RBC
Microcytosis
Small RBC
Polycythemia
Abnormal increase in RBC/hematocrit level
Anticoagulant
Agent that prevents formation of blood clots
Coagulant
Clotting agent
Hemostatic
Agent that stops bleeding
Thrombolytic
Agent that dissolves clots
Remission
Disappearance of disease
Von Willebrands Disease
Hemorrhagic disorder with tendency to bleed from mucus membranes