CHN CU:8 Flashcards
any noxious, unintended, and undesired effects of
a drug which occurs at doses in human for prophylaxis, diagnosis or therapy.
Adverse Drug Reaction (ADR)
any injury that results in medications used
Adverse Drug Event (ADE)
what the body does to the drug
Pharmacokinetic Changes
is an estimate of Glomerular Filtration (GFR) and
decreases with age.
Creatinine clearance
normal creatinine level of male and female
Male : 0.7 – 1.7 mg/dl
Female : 0.4 – 1.4 mg/dl
Used as the gross
measure of glomerular function and the production and
excretion of urea.
Blood Urea Nitrogen (BUN)
normal BUN level
7-23 mg/dl
Indicator of liver disease
Alkaline Phosphatase
normal level of alkaline phosphatase
34-122 u/l
what then drug does to the body?
Pharmacodynamic Changes
the presence or absence of any food that may reduce or
increase the bioavailability of a medication, leading to unanticipated effects
Drug-Food Interactions
an interaction between one drug and another can result from altered pharmacokinetics or
pharmacodynamics.
DRUG-DRUG INTERACTION
Certain disease states may be exacerbated by specific drug therapies, and these
drugs may be contraindicated in patients with a coexisting underlying disease
Drug-Disease Interactions
Prescription, administration, or use of more medications than are clinically
indicated in a given patient.
Polypharmacy
Problems with medication use in the nursing facility have prompted federal legislation
Omnibus Budget Reconciliation Act (OBRA) 1987