CHN CU:8 Flashcards
any noxious, unintended, and undesired effects of
a drug which occurs at doses in human for prophylaxis, diagnosis or therapy.
Adverse Drug Reaction (ADR)
any injury that results in medications used
Adverse Drug Event (ADE)
what the body does to the drug
Pharmacokinetic Changes
is an estimate of Glomerular Filtration (GFR) and
decreases with age.
Creatinine clearance
normal creatinine level of male and female
Male : 0.7 – 1.7 mg/dl
Female : 0.4 – 1.4 mg/dl
Used as the gross
measure of glomerular function and the production and
excretion of urea.
Blood Urea Nitrogen (BUN)
normal BUN level
7-23 mg/dl
Indicator of liver disease
Alkaline Phosphatase
normal level of alkaline phosphatase
34-122 u/l
what then drug does to the body?
Pharmacodynamic Changes
the presence or absence of any food that may reduce or
increase the bioavailability of a medication, leading to unanticipated effects
Drug-Food Interactions
an interaction between one drug and another can result from altered pharmacokinetics or
pharmacodynamics.
DRUG-DRUG INTERACTION
Certain disease states may be exacerbated by specific drug therapies, and these
drugs may be contraindicated in patients with a coexisting underlying disease
Drug-Disease Interactions
Prescription, administration, or use of more medications than are clinically
indicated in a given patient.
Polypharmacy
Problems with medication use in the nursing facility have prompted federal legislation
Omnibus Budget Reconciliation Act (OBRA) 1987
Omission or commission of an act that departs from acceptable and reasonable
standards, which can take several forms
ETHICAL PRINCIPLES
committing an unlawful or improper act.
Malfeasance
performing an act improperly
Misfeasance
failure to take proper action
Nonfeasance
failure to abide by the standards of one’s profession
Malpractice
disregard to protection the safety of another person
Criminal negligence
refers to loyalty and a championing of the needs and interest of others, to educate and informed the patients about their rights and access benefits entitled for them
ADVOCACY
is the concept that each person has a right to make independent choices and
decisions
AUTONOMY
concepts of do good
BENEFICENCE