Charter 107: Noncytotoxic Agents Flashcards
hormonal agents are used for
breast and prostate cancer
hormonal agents mechanism of action
mimic or block the actions of endogenous hormones
what are the two major drug groups used to treat cancer
- Antiestrogens
- aromatase inhibitors
antiestrogens examples
Tamoxifen [Nolvadex]
aromatase inhibitor examples
anastrozole [Arimidex]
adjuvant agents
- monoclonal antibodies like trastuzumab [herceptin]
_ in _ women will develop breast cancer during their lifetime
1 in 8
_ in _ women will die from breast cancer
1 in 36
tamoxifen [nolvadex] is used as an established treatment for
breast cancer disease
tamoxifen [Nolvadex] mechanism of action
blocks estrogen receptors on breast cancer cells that are ER positive
tamoxifen dose
20mg daily
tamoxifen adverse effects
- hot flashes, fluid retention, vaginal discharge, nausea and vomiting, mentral irregularities, endometrial cancer, tetrogenic
_ in _ men will develop prostate cancer during their lifetime
1 in 8
_ in _ men will die from prostate cancer
1 in 30
localized prostate cancer is treated
with surgery, radiation, postive/negative drugs
metastatic prostate cancer is treated with
drugs, catration
androgen deprivation therapy
- blocks testosterone receptors
- slows disease progression and increases comfort
what is the most commonly used drug for prostate cancer
androgen deprivation therapy
leuprolide [lupron] mechanism of action
supresses production of androgens by testes causing testosterone levels to decline over time
leuprolide [lupron] adverse effects
hot flashes (diminishes over time), aggravate bone pain and urinary obstruction
what can reduce the adverse effects of leuprolide [lupron]
co treatment with androgen receptor blocker
leuprolide [lupron] is administered
subcut or IM
target drugs are designed to
bind with specific molecules that drive tumor growth
what are the largest group of targeted drugs
kinase inhibitors
