Charter 107: Noncytotoxic Agents

Question 1

hormonal agents are used for

Answer 1

breast and prostate cancer

Question 2

hormonal agents mechanism of action

Answer 2

mimic or block the actions of endogenous hormones

Question 3

what are the two major drug groups used to treat cancer

Answer 3

• Antiestrogens
• aromatase inhibitors

Question 4

antiestrogens examples

Answer 4

Tamoxifen [Nolvadex]

Question 5

aromatase inhibitor examples

Answer 5

anastrozole [Arimidex]

Question 6

adjuvant agents

Answer 6

• monoclonal antibodies like trastuzumab [herceptin]

Question 7

_ in _ women will develop breast cancer during their lifetime

Answer 7

1 in 8

Question 8

_ in _ women will die from breast cancer

Answer 8

1 in 36

Question 9

tamoxifen [nolvadex] is used as an established treatment for

Answer 9

breast cancer disease

Question 10

tamoxifen [Nolvadex] mechanism of action

Answer 10

blocks estrogen receptors on breast cancer cells that are ER positive

Question 11

tamoxifen dose

Answer 11

20mg daily

Question 12

tamoxifen adverse effects

Answer 12

• hot flashes, fluid retention, vaginal discharge, nausea and vomiting, mentral irregularities, endometrial cancer, tetrogenic

Question 13

_ in _ men will develop prostate cancer during their lifetime

Answer 13

1 in 8

Question 14

_ in _ men will die from prostate cancer

Answer 14

1 in 30

Question 15

localized prostate cancer is treated

Answer 15

with surgery, radiation, postive/negative drugs

Question 16

metastatic prostate cancer is treated with

Answer 16

drugs, catration

Question 17

androgen deprivation therapy

Answer 17

• blocks testosterone receptors
• slows disease progression and increases comfort

Question 18

what is the most commonly used drug for prostate cancer

Answer 18

androgen deprivation therapy

Question 19

leuprolide [lupron] mechanism of action

Answer 19

supresses production of androgens by testes causing testosterone levels to decline over time

Question 20

leuprolide [lupron] adverse effects

Answer 20

hot flashes (diminishes over time), aggravate bone pain and urinary obstruction

Question 21

what can reduce the adverse effects of leuprolide [lupron]

Answer 21

co treatment with androgen receptor blocker

Question 22

leuprolide [lupron] is administered

Answer 22

subcut or IM

Question 23

target drugs are designed to

Answer 23

bind with specific molecules that drive tumor growth

Question 24

what are the largest group of targeted drugs

Answer 24

kinase inhibitors