Chapter 10: Introduction to Immunomodulators Flashcards

1
Q

Monoclonal Antibodies (mAbs)

A
  • protein (antibody) derived from a human, a mouse or rodent, or a combination of the two
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2
Q

cells with antibodies are combined with tumor cells to form

A

hybridomas

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3
Q

mAbs work at the site of

A

cell membrane receptors

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4
Q

mAbs function

A
  • target specific antigens
  • activate bodies natural immune response
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5
Q

mAbs common applications

A
  • cancer
  • asthma
  • hemophilia
  • prevention of migraine headache
  • C. difficile
  • MS
  • rheumatoid arthritis
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6
Q

monoclonal antibodies for asthma

A

omalizumab [Xolair]

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7
Q

omalizumab [Xolair] mechanism of action

A

combines free IgE, decreasing mast cell activation (decreased airway bronchospasm and inflammation)

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8
Q

Common adverse reactions to mAbs

A
  • immunogenicity
  • anaphylaxis
  • cytokine release syndrome
  • non-acute reactions
  • toxicity
  • dematologic
  • GI
  • hepatic
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9
Q

Common tyrosine kinase inhibitor toxicities

A
  • dermatologic
  • GI (diarrhea, stomatitis)
  • Protease inhibitors “Mibs” (build up causes cell dealth)
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10
Q

common proteasome Inhibitor toxicities

A
  • cardiologic (not common, heart failure, arythmias)
  • GI (nausea, vomiting, diarrhea, constipation0
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11
Q

areas of current research include

A
  • immunotherapy for aging
  • advanced solid tumors
  • IgA neuropathy
  • Parkinsons Disease
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