Chapter 10: Introduction to Immunomodulators Flashcards
1
Q
Monoclonal Antibodies (mAbs)
A
- protein (antibody) derived from a human, a mouse or rodent, or a combination of the two
2
Q
cells with antibodies are combined with tumor cells to form
A
hybridomas
3
Q
mAbs work at the site of
A
cell membrane receptors
4
Q
mAbs function
A
- target specific antigens
- activate bodies natural immune response
5
Q
mAbs common applications
A
- cancer
- asthma
- hemophilia
- prevention of migraine headache
- C. difficile
- MS
- rheumatoid arthritis
6
Q
monoclonal antibodies for asthma
A
omalizumab [Xolair]
7
Q
omalizumab [Xolair] mechanism of action
A
combines free IgE, decreasing mast cell activation (decreased airway bronchospasm and inflammation)
8
Q
Common adverse reactions to mAbs
A
- immunogenicity
- anaphylaxis
- cytokine release syndrome
- non-acute reactions
- toxicity
- dematologic
- GI
- hepatic
9
Q
Common tyrosine kinase inhibitor toxicities
A
- dermatologic
- GI (diarrhea, stomatitis)
- Protease inhibitors “Mibs” (build up causes cell dealth)
10
Q
common proteasome Inhibitor toxicities
A
- cardiologic (not common, heart failure, arythmias)
- GI (nausea, vomiting, diarrhea, constipation0
11
Q
areas of current research include
A
- immunotherapy for aging
- advanced solid tumors
- IgA neuropathy
- Parkinsons Disease