Chapter 106: Cytotoxic Agents Flashcards
what is the largest class of anticancer drugs
cytotoxic anticancer drugs
cytotoxic anticancer drugs mechanism of actions
act directly on cancer cells and healthy cells to cause their death
what percentage of cytotoxic drugs are phase specific
50%
how many major groups are cytotoxic drugs divided into
8
what are the 8 categories of cytotoxic drugs
- Alkylating agents
- platinum compounds
- antimetabolites
- hypomethylating agents
- antitumor antibiotics
-mitotic inhibitors - topoisomerase inhibitors
- miscellaneous cytotoxic drugs
cell cycle
sequence of events that a cell goes through from one miotic division to the next
cell-cycle phase-specific drugs
- toxic only to cells in a particular phase
- must be in the blood continously over a long time
cell-cycle phase-nonspecific drugs
- can act during any phase of the cell cycle
anticancer drugs are especially toxic to tissues
with a high growth fraction
examples of tissues with a high growth fraction
- bone marrow
- hair follicles
- GI epithelium
- germinal epithelium (reproductive tract)
antineoplastic drugs are often ____, ____, and ______
mutagenic
teratogenic
carcinogenic
high alert medications means
they cause devastating effects to patients in the events of a medication error
antimetabolites
folic acid analogues
folic acid analogues example
methotrexate
methotrexate mechanism of action
inhibits dihydrofolate reductase, thus interfering with the production of folic acid
