Chapter 97: Antiviral Agents: Drugs for NOn-HIV VIral Infections

Question 1

Acyclovir [Zovirax] mechanism of actions

Answer 1

suppresses synthesis of viral DNA

Question 2

Acyclovir [Zovirax] is used for

Answer 2

Herpes simplex (mucocutaneous genitalis), Varicella-Zoster (herpes zoster, varicella)

Question 3

Acyclovir is excreted through

Answer 3

renal

Question 4

Acyclovir dosing

Answer 4

3-5x/day

Question 5

Famciclovir [famvir]

Answer 5

• prodrug used to treat acute herpes zoster or genital herpes
• adverse effects are minimal

Question 6

topical drugs for herpes labialia

Answer 6

• penciclovir
• docosanol [Abreva]

Question 7

ocular herpes infection drugs

Answer 7

• Trifluridine [Viroptic]
• Ganciclovir 0.15% ophthalmic gel

Question 8

chronic hepatitis can be cuased by striand

Answer 8

D, C, D

Question 9

transmission of hepatitis C virus

Answer 9

primarily throughthe exchange of blood; controversy over sexual transmission

Question 10

Hep C drugs

Answer 10

• pegylated interferon alfa combined with ribavirin

Question 11

Interferon Alfa [intron-A] adverse effects

Answer 11

• flu like symptoms
• neuropsychiatric effects, especially depression
• fatigue, thyroid dysfunction, heart damage, and bone marrow supression, manifesting as neutropenia and thrombocytopenia