Chapter 97: Antiviral Agents: Drugs for NOn-HIV VIral Infections Flashcards
1
Q
Acyclovir [Zovirax] mechanism of actions
A
suppresses synthesis of viral DNA
2
Q
Acyclovir [Zovirax] is used for
A
Herpes simplex (mucocutaneous genitalis), Varicella-Zoster (herpes zoster, varicella)
3
Q
Acyclovir is excreted through
A
renal
4
Q
Acyclovir dosing
A
3-5x/day
5
Q
Famciclovir [famvir]
A
- prodrug used to treat acute herpes zoster or genital herpes
- adverse effects are minimal
6
Q
topical drugs for herpes labialia
A
- penciclovir
- docosanol [Abreva]
7
Q
ocular herpes infection drugs
A
- Trifluridine [Viroptic]
- Ganciclovir 0.15% ophthalmic gel
8
Q
chronic hepatitis can be cuased by striand
A
D, C, D
9
Q
transmission of hepatitis C virus
A
primarily throughthe exchange of blood; controversy over sexual transmission
10
Q
Hep C drugs
A
- pegylated interferon alfa combined with ribavirin
11
Q
Interferon Alfa [intron-A] adverse effects
A
- flu like symptoms
- neuropsychiatric effects, especially depression
- fatigue, thyroid dysfunction, heart damage, and bone marrow supression, manifesting as neutropenia and thrombocytopenia
12
Q
Hep B is transmitted through
A
blood and semen
13
Q
chronic Hep B can lead to
A
cirrhosis, heptic failure, helatocellular carcinoma, and dealth
14
Q
additional hep C drugs
A
- Protease inhibitors (simeprevir)
- NS5A inhibitors
- NS5B nucleoside polymerase inhibitors
- Nucleoside analogues (ribavirin)
15
Q
Hep B drugs
A
- vaccine
- interferon alfa-2b
- peginterferon alfa-2a
- lamivudine (Heptovir)
- telbivudine (sebivo)
