Chapter 50: Drugs for Hypertension Flashcards

1
Q

what are the 4 risk factors for hypertension

A
  • diabetes mellitus
  • chronic kidney disease
  • low level of consumption of fresh fruits and vegetables
  • sedentary behaviour
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2
Q

out of office measurement of blood pressure is reccomended for all adults with

A
  • high BP in office to rule out white coat hypertension
  • suspected hypertension yo rule out masked hypertension
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3
Q

normal blood pressure

A

systolic BP <120 and diastolic BP < 80

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4
Q

elevated BP

A

systolic BP of 120-129 and diastolic <80

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5
Q

hypertension stage 1

A

systolic BP 130-139 or dialstolic 80-89

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6
Q

hypertesnion stage 2

A

systolic BP >140 or diastolic BP >90

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7
Q

what is the target blood pressure for someone with diabetes

A

<130

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8
Q

consequences of hypertension

A
  • increased risk of stroke and ischemic heart disease mortality
  • for every 20 systolic BP; risk of dying doubles
  • for every 10 diastolic BP; risk doubles
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9
Q

Primary (essential) hypertension

A
  • no identifiable cause
  • chronic, progressive disorder
  • population: older adults, african Canadians, postmenopausal women
  • treated no cured
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10
Q

secondary hypertension

A
  • identifiable primary cause
  • possible to treat the cause directly
  • some individuals can be cured (hypertension during pregnancy or a tumour)
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11
Q

masked hypertension

A
  • patients BP is less than 140/90 in a medical setting but is hypertensive at home
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12
Q

white coat hypertension

A
  • patients BP is less than 140/90 at home but is hypertensive in a medical setting
  • associated with anxiety and nervousness
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13
Q

hypertension is a significant risk factor for

A
  • cerebrovascular disease
  • coronary artery disease
  • heart failure
  • renal failure
  • peripheral vascular disease
  • dementia
  • atrial fibrillation
  • kidney disease
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14
Q

major cardiovascular risk factors

A
  • cigarette smoking
  • physical inactivity
  • dyslipidemia
  • diabetes
  • microalbuminuria
  • advances age (older 55 men; older 65 women)
  • family history
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15
Q

lifestyle modifications for hypertension

A
  • sodium restriction
  • DASH eating plan
  • alcohol restriction
  • aerobic exercise / weight reduction
  • smoking cessation
  • maintenance of potassium and calcium intake
  • relaxation therapies
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16
Q

sodium intake should be

A

<2000 mg/day

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17
Q

how much physical activity should someone do

A

30-60 min 4-7 days/week

18
Q

appropriate alcohol intakw

A

0-2 drinks per day

19
Q

stress management

A

CBT and relaxation techniques

20
Q

what is healthy BMI

A

18.5-24.9kg/m

21
Q

healthy waist circumference

A

men <102cm
women <88cm

22
Q

arterial pressure =

A

cardiac output x peripheral resistance

23
Q

cardiac output is influenced by

A
  • heart rate
  • myocardial contractility
  • blood volume
  • venous return
24
Q

what are the systems that help regulate blood pressure

A
  • SNS: sympathetic baroreceptor reflex
  • RAAS
  • kidney: renal regulation of blood pressure
25
Q

what are the sites of drug action

A
  • brainstem
  • sympathetic ganglia
  • terminals of adrenergic nerves
  • beta 1 adrenergic receptors on the heart
  • alpha 1 adrenergic receptors on blood vessels
  • renal tubules
  • RAAS
26
Q

what are the classes of hypertensive drugs

A
  • Diuretics
  • Sympatholytics (antiadrenergic drugs)
  • direct acting vasodilators (hydralazine and minoxidil)
  • calcium channel blockers (diltiazem, verapamil)
  • drugs that supress RAAS (ACE inhibitors, ARBS, aldosterone antagonists)
27
Q

patients without compelling inducations will be put on which drug

A

long-acting thiazide-like diuretics
- Indapamide
or single pill combinations

28
Q

patients with compelling indications will be put on which drugs

A
  • beta blocker
  • ACE
  • ARB
  • CCB
  • duiretic
29
Q

What drugs should be used in patients with renal disease

A

ACE or ARB

30
Q

what drugs should be used in patients with diabetes

A

may need multiple drugs

31
Q

what drugs should be used in african Canadians

A

diuretics are first choice

32
Q

what drugs should be avoided in females

A

ACE/ARB

33
Q

what drugs should be used in older adults

A
  • start with low dose diuretic
34
Q

what are ways to promote adherence

A
  • educate the patient
  • teach self-monitoring
  • minimize side effects
  • establish a collaborative relationship (patient centered care)
  • simplify the regimen
  • other measures (motivational interviewing)
35
Q

possible reasons for poor response to treatment

A
  • adherence (dietary, activity, meds)
  • obestity, tobacco, alcohol, sleep apnea, chronic pain
  • suboptimal treatment dose
  • volume overload- high sodium intake
  • drug interactions
36
Q

drugs for hypertensive emergencies

A
  • sodium nitroprusside [Nitropress]
  • Labetalol
37
Q

sodium nitroprusside [nitropress]

A
  • continuous IV infusion via pump
  • direct acting vasodilator
38
Q

Labetalol

A
  • alpha/beta blocker
  • slow IV
39
Q

what drugs shoul dbe used for hypertension during pregnancy

A
  • labetolol
  • methydopa
  • LA nifedipine
  • beta blockers
40
Q

what drugs are contradicted during pregnancy

A
  • ACE
  • ARB
  • DRI
41
Q

what drugs are use for preeclampsia and eclampsia

A
  • hydralazine
  • magnesium sulfate
42
Q

what may aggravate low blood pressure q

A
  • hot tubes, showers, baths, hot weather, prolonged sitting or standing, physical exercise, and alcohol ingestion