Chapter 22: Indirect Acting Antiadrenergic Agents

Question 1

Indrirect acting antiadrenergic agents purpose

Answer 1

prevent stimualtion of peripheral adrenergic receptors

Question 2

what are the 2 groups of antiadrenergic agents

Answer 2

• adrenergic neuron-blocking agents
• centrally acting alpha2 agonists

Question 3

Adrenergic neuron blocking agents

Answer 3

• decrease norepinephrine (NE) release

Question 4

centrally acting alpha2 agonists

Answer 4

• reduce impulses along the sympathetic nerves

Question 5

Centrally acting alpha2 agonists are used primarily for

Answer 5

hypertension

Question 6

examples of centrally acting Alpha2 agonists

Answer 6

• clonidine (catapres)
• guanfacine
• methyldopa

Question 7

Clonidine effects

Answer 7

• reduces sympathetic outflow into blood vessels and heart (anithypertensive)
• bradycaria
• decreased cardiac output
• minimal orthostatic hypotension

Question 8

Therapeutic uses of clonidine

Answer 8

• hypertension
• severe pain
• management of ADHD

Question 9

adverse effects of clonidine

Answer 9

• drowsiness (35% of patients)
• xerostomia (40% of patients)
• rebound hypertension
• constipation, impotence, gynecomastia, and CNS effects