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HLST220: Pharmacology > Chapter 16: Muscarinic Agonists > Flashcards

Chapter 16: Muscarinic Agonists Flashcards

1
Q

cholinergic drugs

A
  • agents that influence the activity of cholinergic receptors
  • most mimic or block actions of acetylcholine
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2
Q

what do most cholinergic drugs mimic or block the actions of

A

acetylcholine

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3
Q

cholinesterase inhibitors

A
  • indirectly prevent the breakdown of acetylcholine
  • can be vey toxic (insecticides, chemical warefare)
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4
Q

Muscarinic Agonists

A

produce effects through indriect interaction with muscarinic receptors

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5
Q

muscarinic agonists example

A

bethanechol

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6
Q

what are the principle structures affected by muscarinic activation

A

heart, exocrine glands, smooth muscles, and eyes

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7
Q

bethanechol [Duvoid] effect on the heart

A

bradycardia

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8
Q

bethanechol [Duvoid]

A
  • parasympathomimetic agent
  • selective agonist at muscarinic receptors
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9
Q

Bethanechol [Duvoid] effect on the lungs

A

constriction of the bronchi

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10
Q

Bethanechol [Duvoid] effect on GI

A

increased tone and mobility

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11
Q

Bethanechol [Duvoid] effect on bladder

A

contraction of detrusor muscle and relaxation of the trigone and sphincter

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12
Q

Bethanechol [Duvoid] effect on exocrine glands

A

increased sweating, salivation, broncial secretions, and secretions of gastric acid

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13
Q

Bethanechol [Duvoid] effect on the eye

A

Miosis and contraction of the ciliary muscles

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14
Q

Bethanechol [Duvoid] therapeutic uses

A

urinary retention

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15
Q

Bethanechol [Duvoid] adverse effects

A

hypotension, increased tone and motility, exacerbation of asthma, dysrhythmias in patients with hyperthyroidism

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16
Q

Bethanechol [Duvoid] contraindindicartions

A

Gi ulcers, intestinal obstruction

17
Q

other muscarinic agonists

A
  • pilocarpine
  • acetylcholine
18
Q

pilocarpine

A

Muscainic agonist
- used mainly for topical therapy of glaucoma

19
Q

Acetylcholine

A

Muscarinic Agonist
- used for rapid miosis (pupil constriction) in cataract surgery

20
Q

treat overdose of Muscarinic Agonists with

A

atropine

21
Q

Muscarinic Agonists effects

A

BLUCHPADS BBC
- bradycardia
- lacrimination
- urination
- salivation
- hypotension
- pinpoint pupils (miosis)
- acomodation
- defecation (increased GI mobility)
- sweating
- bronchoconstriction
- cronchosecretion
- CNS dysfunction

22
Q

sources of toxicology of muscarinic agonists

A

ingestion of certain muschrooms, direct-acting muscarinic agonists, and cholinesterase inhibitors

23
Q

symptoms of toxicology in muscarinic agonists

A
  • salvation, lacrimation (tearing), visual distrurbannces, bronchospasms, diarrhea, bradycardia, and hypotension with possible cardiovascular collapse
24
Q

muscarinic agonists effect on vascular structures

A

relaxation, vasodilation, and hypotension

HLST220: Pharmacology (23 decks)

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