Chapter 16 lecture 3 Flashcards
Who does graft versus host disease occur in?
-Recipients of allogeneic bone marrow transplantations
If a person has chronic CVHD what percent have oral involvement?
-80%
What do oral lesions of GVHD look like?
-Lichen planus
What is used to treat focal oral ulcerations in GVHD?
Topical corticosteroids
What is the most common collagen vascular or connective tissue disease in the US?
-Lupus Erythematous
What are the common findings of SLE?
- Fever
- Weight loss
- Arthritis
- Fatigue
- Malar rash (butterfly rash)
What can make the malar rash worse in SLE?
-Sunlight
What is the most significant aspect of SLE?
-Kidney failure
Up to 50% of SLE have warty vegetations affecting heart valves termed what?
Libman-Sacks endocarditis
What is mild Lupus Erythematous managed by?
- NSAIDS
- Antimalarial (hydroxychloroquine)
What is the first sign of systemic sclerosis?
-Raynauds Phenomenon
What is a disease in which dense collagen is deposited in the tissues of the body in extraordinary amounts?
-Systemic sclerosis
What is Raynauds Pehnomenon?
- Vasoconstrictive triggered by emotional distress or exposure to cold
- Not specific for systemic sclerosis
Characteristic furrows radiating from the mouth produce a purse string appearance in what disease?
-Systemic sclerosis
T/F Pts with systemic sclerosis have a 70% reduction in opening of the mouth
True
What is a mild variant of systemic sclerosis known as?
-Localized scleroderma
Localized scleroderma has lesions that look like scars termed what?
-En coup de sabre “strike of the sword”
What is CREST syndrome?
- Calcinosis cutis
- Raynauds phenomenon
- Esophageal dysfunction
- Sclerodactyly
- Telangiectasia
Benign acanthosis nigricans may be caused by what?
- Obesity
- Inheritance
- Various endocrinopathies
- Various syndromes
- Various drugs
If you have benign acanthosis nigricans caused by obesity what is that termed?
-Pseudoacanthosis nigricans
In acute GVHD the skin lesions range from a mild rash to diffuse and sever sloughing that resembles what?
-Toxic epidermal necrolysis
What does chronic GVHD mimic?
- SLE
- Sjogrens syndrome
What are the different types of Lupus erythematosus
- SLE
- Chronic cutaneous lupus erythematous
- Subacute cutaneous lupus erythematous
What does acanthsis nigricans appear like?
- Velvety
- Brown
Which lesions of acanthisis nigricans are benign?
-Cutaneous lesions
