Chapter 10 Epithelial pathology Flashcards
What is a benign proliferation of stratified squamous epithelium?
-Squamous papilloma
What causes squamous papilloma?
-Human papillomavirus type 6 and type 11
What type of virus is HPV?
-DNA Papovavirus
T/F Squamous papilloma has extremely low virulence and infectivity rate
True
What is virulence?
-Ability of virus to overcome body’s defenses and cause disease
What is infectivity?
-Ability to establish infection from one person to another horizontally
What are the sites of predilection of Squamous papilloma?
- Tongue
- Lips
- Soft palate
T/F Papillomas can be pedunculated
True
What are the differential diagnosis that appear like squamous papilloma?
- Verruca vulgaris
- Condyloma acuminatum
- Verruciform xanthoma
What is a common wart known as?
-Verruca Vulgaris
What HPV types cause Verruca vulgaris?
- 2
- 4
- 6
- 40
What HPV types are associated with squamous papilloma?
- 6
- 11
T/F Verruca vulgaris is not contagious
False
-It is contagious
What does an oral verruca vulgaris appear as?
-White pebbly surface
What is Condyloma Acuminatum aka?
-Venereal wart
T/F Condyloma acuminatum is considered a sexually transmitted disease
True
What HPV types cause Condyloma acuminatum?
- 6 -most common
- 11- most common
- 16
- 18
- 31
What is the size of condyloma acuminatum?
-1-1.5 cm
If the condyloma acuminatum are HPV type 16 or 18 found in the anogenital area what are they at increased risk for?
-Malignant transformation to squamous cell carcinoma
What is multifocal epithelial hyperplasia aka?
-Heck’s disease
What types of HPV cause Heck’s disease (multifocal epithelial hyperlpasia?
- HPV -13
- HPV 32
What type of patient does Heck’s disease appear in?
-Children but it lasts for life
What are benign localized proliferations of respiratory mucosa known as?
-Sinonasal papillomas
What are the three distinct patterns of sinonasal papillomas?
- Fungiform
- Inverted
- Cylindrical cell
What type of virus is Molluscum Contagiosum?
-DNA poxvirus
What does the histopathology of Molluscum contagiosum have?
-Henderson-Paterson bodies
What is characterized by lipid-laden histiocytes in the epithelium?
-Verruciform Xanothoma
Seborrheic keratosis is extremely common in what population?
-Older people
What is a form of Seborrheic keratosis that occurs in 30% of African Americans?
-Dermatosis papulosa nigra
What is the sudden appearance of numerous seborrheic keratoses with pruritus called and has been associated with interal malignancy?
-Leser-Trelat sign
What is Ephelis aka?
-Freckle
What causes ephelis to become for pronounced?
-Sun exposure
What is a benign brown macule resulting from chronic UV light damage to the skin?
-Actinic Lentigo
If the person has freckles that don’t become more pronounced from sun exposure what is it called?
-Actinic Lentigo
What is a benign cutaneous melanocytic hyperplasia known as?
-Lentigo simplex
What is a hormonally driven hyper-pigmentation of sun-exposed skin of the face known as?
-Melasma
What is Melasma classically associated with?
-Pregnancy
