Calculating drug dosages Flashcards
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6
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How can metabolic rate be calculated?
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Minimum energy cost (kcal/day) =
K x (weight in kg)0.75, where K is a energy constant
7
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What is allometric scaling?
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drugs are sometimes administered based on the animals surface area or metabolic rate
8
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Why is surface area sometimes used to calculate drug dose?
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As function of organs responsible for detoxification (i.e.kidney/liver) are more closely related to surface area than body weight
9
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When is metabolic rate used to calculate dosage?
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In species where the dose is unknown (e.g. many exotic/zoo species)
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