BS: The Gross Structure Flashcards

1
Q

Bone structure has three levels:

A
  1. gross
  2. microscopic
  3. chemical
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2
Q

Dense outside layer […] surrounds the inside […].

A

compact; spongy

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3
Q

Internal to the spongy bone (also known as trabecular bone) lies…

A

trabeculae– honeycomb of small flat pieces

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4
Q

What is in between trabeculae?

A

red or yellow marrow

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5
Q

For flat bones […] bone sandwiches […].

A

spongy; compact

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6
Q

Which bones share a simple pattern?

A
  1. short
  2. irregular
  3. flat
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7
Q

What are the 4 parts of the simple pattern short/irregular/flat bones?

  • sif bones
A

compact bone covers spongy

spongy contains bone marrow between trabeculae but no defined cavity

bone is covered in and out by connective tissue membranes

joints covered by hyaline cartilage

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8
Q

Thin plates of spongy bone also known as…

A

diploe

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9
Q

The connective tissue membranes of sif bones?

A

periosteum (outside) and endosteum (inside)

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10
Q

LB: What is the general structure of long bones?

A

a shaft, bone ends, and membranes

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11
Q

LB: A tubular […], also known as the shaft, forms the long […] of the bone.

A

diaphysis; axis

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12
Q

LB: The thick collar of […] bone surrounds a central […] cavity or […] cavity.

A

compact; medullary; marrow

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13
Q

LB: What are the bone ends?

A

epiphyses

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14
Q

LB: What forms the epiphyses?

A

compact bone extension (exterior)

spongy bone (interior)

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15
Q

LB: What covers the surface of the epiphyses?

A

thin layer of articular/hyaline cartilage

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16
Q

LB: What is the purpose of the articular/hyaline covering?

A

cushioning during movement and absorbing stress

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17
Q

LB: Between the diaphysis and each epiphysis is an […] line.

A

epiphyseal

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18
Q

LB: The epiphyseal plate is located…

A

at the junction of the epiphyseal and diaphysis

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19
Q

LB: The epiphyseal plate ([…] plate), is a disc of […] cartilage that grows during childhood.

A

growth; hyaline

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20
Q

LB: The flared middle portion of the bone where the diaphysis and epiphysis meet

A

metaphysis

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21
Q

LB: Periosteum covers the […] surface EXCEPT the […] surfaces.

A

external; joint

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22
Q

LB: The periosteum/endosteum has two layers:

A

fibrous (outer)

osteogenic (inner)

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23
Q

LB: The fibrous outer layer of the periosteum is […] connective tissue.

A

dense

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24
Q

LB: The inner periosteum layer contains what type of cells?

A

osteoprogenitor cells (osteogenic)
osteoclasts
osteoblasts

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25
Q

LB: What are the osteoprogenitor cells?

A

primitive stem cells give rise to most bone cells

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26
Q

LB: Why are broken bones so painful?

A

The periosteum is richly supplied with nerve fibers and blood vessels

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27
Q

LB: The periosteum also provides […] points for tendons/ligaments.

A

anchoring

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28
Q

LB: What are perforating fibers? Where can you find them?

A

bundles of collagen fibers that secure the layer to the bone by extending to the matrix

in the periosteum layer

perforating: pierce/make holes

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29
Q

LB: The endosteum covers […] bone surface both spongy and compact.

A

internal

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30
Q

LB: What cells are within the endosteum?

A

the same as the periosteum

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31
Q

What are the main vessels serving the diaphysis?

A

nutrient artery and nutrient vein

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32
Q

Where do the blood vessels and nerves run through?

A

nutrient foramen– an opening in the diaphysis wall

33
Q

Pathway of blood and nerve vessels:

A

diaphysis—nutrient foramen—bone marrow/spongy bone—branches to compact

34
Q

Red marrow also known as…

A

hematopoietic (blood forming tissue)

35
Q

Where do children house red marrow?

A

the medullary cavity of the diaphysis and all areas of spongy bone

36
Q

Where do adults house red marrow?

A

small amount in between trabeculae

37
Q

Why is there little red marrow within the long bones of an adult?

A

most of it has been replaced by yellow marrow

38
Q

In which bones can you find red marrow?

A

LB: femur and humerus
FB: skull, sternum, ribs, clavicles, scapulae
IB: hip bones and vertebrae

39
Q

How can an adult revert to red marrow?

A

if they become anemic

40
Q

Bone marking can fit into 3 categories:

A
  1. projections
  2. surfaces
  3. depressions/opening
41
Q

Projections:

A

site of muscle and ligament attachment

42
Q

Surfaces:

A

form joints

43
Q

Depressions/openings:

A

for blood/nerve vessels

44
Q

What are the 5 major cell types:

A
  1. osteoprogenitor
  2. osteoblasts
  3. osteoclasts
  4. bone lining cells
  5. osteocytes
45
Q

All of these except for the […] originate from embryonic connective tissue cells.

A

osteoclasts

46
Q

What is the process remodeling?

A

cells continuously resorb and deposit

47
Q

In growing bones, […] cells are flattened or squamous.

A

osteogenic

48
Q

When osteogenic cells are stimulated, some of these cells turn to […].

A

osteoblasts

49
Q

Osteoblasts secretions includes:

A
  1. collagen (90%)

2. calcium-binding proteins

50
Q

What do calcium-binding proteins create?

A

the initial, un-mineralized bone (osteoid)

51
Q

Matrix calcification is done by […] cells.

A

osteoblasts

52
Q

Osteocytes occupy what spaces?

A

lacunae

53
Q

What are the 3 function of osteocytes?

A

maintain and monitor bone matrix

respond to mechanical stimuli

trigger bone remodeling

54
Q

Osteocyte trigger bone remodeling due to mechanical […] or to maintain […] homeostasis.

A

stress; calcium

55
Q

Where can you find bone lining cells?

A

on surfaces where bone remodeling is not going on

56
Q

What is the purpose of bone lining cells?

A

maintain the matrix

57
Q

Osteoclasts are giant […] cells located at sites of bone […].

A

multinucleate; resorption

58
Q

Where are osteoclasts derived from?

A

WBC lineage that creates macrophages

59
Q

Osteoclasts lie in a shallow […].

A

depression

60
Q

Osteoclasts have a distinct […] border that […] contacts the bone.

A

ruffled; directly

61
Q

What is the purpose of the osteoclasts ruffled border?

A

plasma membrane infoldings increase surface area for enzymatically degrading bones

62
Q

The structural unit of compact bone is […] which is parallel to the long […] of the bone.

A

osteon; axis

63
Q

What is the function of osteons?

A

tiny weight-bearing pillars

64
Q

What is the matrix tube of osteons called?

A

lamella

65
Q

Osteon’s design as a “twister resister” is due to what?

A

collagen fibers running in different directions to withstand torsional stresses

66
Q

How can collagen fibers within lamella alternate their direction?

A

tiny crystals of bone lamellae

67
Q

What is in the core of each osteon?

A

central canal (Haversian canal)

68
Q

What does the core of each osteon contain?

A

small blood vessels and nerve fibers (serve the cells)

69
Q

Osteon canals of a second type called […] canals or Volkmann’s canals.

A

perforating

70
Q

Perforating canals lie at […] angles to the long axis of the bone. They connect […] and […] supply of the […] cavity to central canals.

A

right; blood vessels; nerve fibers; medullary

71
Q

Perforating canals are not surrounded by […].

A

lamellae

72
Q

Osteocytes occupy […] at the junctions of lamellae.

A

lacunae

73
Q

Hairlike canals called […] radiate from the […] connecting them to each other and to the central canal/

A

canaliculi; lucanae

74
Q

Osteon = […]

A

Haversian System

75
Q

What is the structural unit of compact bone?

A

osteon

76
Q

Lamellae:

A

compact bone matrix consisting of a cylinder with many rings

77
Q

What contributes to the hardness of bone?

A

hydroxyapatite– makes 65% of the mass

78
Q

What are the inorganic components of the bone matrix?

A

hydroxyapatite