Blood Flashcards
blood overview
- type of connective tissue
- two main portions: liquid + cells
liquid of blood
plasma
formed elements
the cells found in blood: red blood cells, white blood cells, and platelets
serum
- plasma with the clotting factors removed
- commonly used for lab tests
functions of plasma (4)
- helps buffer pH of blood
- aids in coagulation (blood clotting)
- assists in transporting large organic molecules in blood
- contains proteins that maintain blood’s osmotic pressure
pH of blood
~ 7.4
osmotic pressure
- net pressure in blood that moves fluid from tissues into the circulatory system
- maintained by proteins in plasma - naturally attract water from tissues into the capillaries
hydrostatic pressure
pressure of blood pumping from heart that pushes fluid into tissues
osmotic vs. hydrostatic pressure
- oppose each other
- balance of this opposition is important for homeostasis
hemoglobin
- helps red blood cells carry oxygen
- ~250 million hemoglobin molecules per red blood cell
- when old blood cell destroyed, hemoglobin released so iron can be recycled and reused by the red bone marrow
amt red blood cells in blood
4 - 6 million per 1mm3 whole blood
red blood cells overview
- small biconcave disks
- most abundant cell in blood
- anucleate (lose nucleus + synthesize hemoglobin in order to enter blood stream)
- function = carry oxygen
red bone marrow
- found in skull, ribs, vert, ends of long bones
- continuously manufactures red blood cells
life span of red blood cells
- live ~ 120 days
- destroyed by liver and spleen
- hemoglobin is recycled but heme is degraded and excreted by liver as bile pigment
white blood cells overview
- aka leukocytes
- larger than red blood cells
- large nucleus
- no hemoglobin
white blood cells function
inflammatory response to microorganism entering body through injury to blood vessel
how it works:
- blood flow to site of injury increases to bring white blood cells (that’s what causes redness and swelling)
- white blood cells squeeze through capillaries and enter tissue fluid, where destroy any foreign materials
pus
thick yellowish fluid that contains lots of dead white blood cells
3 groups of white blood cells
- granulocytes (contain granules in cytoplasm)
- agranulocytes (no granules in cytoplasm)
- lymphocytes
types of granulocytes (3)
neutrophils
eosinophils
basophils
types of lymphocytes (2)
T-Cells
B-Cells
blood platelets
- aka thrombocytes
- fragments of megakaryocytes (large bone marrow predecessor)
- involved in coagulation – stick to edge of wound + clot the opening, release chemicals to signal coagulation cascade
coagulation cascade
series of events to start blood clotting mechanism
prothombrin activator
- clotting factor
- released by platelets and injured tissue (start of coagulation cascade)
- converts prothombrin to thombrin
thombrin
converts fibrinogen to fibrin
fibrinogen
substance from the liver floating in blood
fibrin
- threads that wind around platelet plug (damaged area) to form framework for clot
- red blood cells get trapped in thread to form red looking clot
plasmin
enzyme that destroys fibrin clot once blood vessel repair begins