bio exp for schizo

Question 1

What does genetic theory suggest

Answer 1

*SZ is hereditary passed from one gen to another
*born w gen predispo to SZ
*sev maladaptive candidate genes like PCM1 involved, increases individuals vulnerability
*108 gen variations associated w risk of developing

Question 2

Research for concordance rates in twins

Answer 2

*Gottesman studied 40 twins
48% conc rate for monozygotic
17% for dizogytic twins
*closer the gen link to someone w schizo, the more chance of developing

Question 3

Explain brain struc/function as a neural correlate

Answer 3

one neural corr is enlarged ventricles
*Raz and Raz found that over half indi tested w SZ had increases ven size compared to control.
*enlarged ven associated w damage of prefrontal cortex and central brain areas- associated w neg symptoms

Question 4

Explain the dopamine hypothesis as a neural correlate

Answer 4

*neurotrasnmitters in ppl w Sz work diff
*dopamine may release too much or have large amount of D2 receptors on post synap

Question 5

Explain what hyper/hypodoperminergia cause in the brain w ppl w SZ- A01

Answer 5

*hyper in subcortex- too much DA ac in central area of brain like Broca’s area, (responsible for speech production)- associated w auditory hallucinations

*hypo in cortex- low DA activity in prefrontal (thinking and dec making) associated w neg symptoms- avoligtion