Bilirubin and Cholestasis Flashcards
Unconjugated bilirubin is water soluble/insoluble?
INSOLUBLE
Where is bilirubin produced? Processed?
Pdx in macrophage
Processed in hepatocytes
conjugated, water soluble, secreted in bile
What is biliprotein
aka delta bilirubin
conjugated bilirubin, irreversible bound to albumin, pdx in hyperbilirubin, long 1/2 life
What are teh 3 bilirubin fractions?
unconjugated
conjugated
delta
In heathy animal ____ predominates in plasma
conjugated
What are the bilirubin measurements?
Total
conjugated/unconjugated
Direct
conjugated only
Indirect
unconjugated only
What is hyperbilirubinemia
increases in un/conjugated bilirubin
may see incterus
What are the 3 types of hyperbilirubinemia?
Pre hepatic
heaptic
Post hepatic
Prehepatic Hyperbilirubinemia
increased pdx
hemolysis/internal hemorrhage
Hepatic hyperbilirubinemia
decreased uptake loss of hepatic fx used to assess liver fasting horses/RMTs spesis
Post hepatic hyperbilirubinemia
obstructive cholestasis
decreased bile secretion
Fx cholestasis
sepsis
What is the haptoglobin recovery system?
alpha globulin pdx in liver
binds free hemoglobim
forms hemoglobin-haptoglobin complex
taken up by hepatocyte
What indicates fasting hyperbilirubinemia?
increased Bu (indirect bilirubin)
w/o any other abnormalities
What do you see when severe cholestasis occurs?
post hepatic hyperbilirubinemia
induction of ALP/GGT
hypercholesterolemia
2ndary heptic damage increases leakage ez
Which form of billirubin do you typically not expect in the urine?
Bu
Bc readily passes through glomerulus
