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Farma 3eras > Antidepresivos > Flashcards

Antidepresivos Flashcards

1
Q

Fluoxetina

A

Inhibidores recaptura de serotonina.
Activador, SV + LARGA (50 h), mucha union a proteinas
Tx TOC, bulimia, depresion melancolica, depresion infantil, ansiedad
Rara abstinencia
ES: Aum peso, mas inhibe al cyp, disfuncion sexual

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2
Q

Fluvoxamina

A

Inhibidores de la recaptura de serotonina
+ Sedante
Tx TOC/depresion en niños y fobia social (agarofobia), tx tept y TAG. Inhibe 1A2

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3
Q

Paroxetina

A

Inhibidor de recaptura de serotonina
+Sedante, inhibidor alosterico de SERT, mucha union a proteina
Tx 1ERA LINEA TEPT, fobia social, TAG, depresion gral, sd disforico premenstrual
ES: inhibe cyp, malformaciones cardiacas, disf sexual, abstinencia, sedante, aum peso
CI: Embarazo (defecto del tabique)

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4
Q

Sertralina

A

Inhibidor de recaptura de serotonina
Inhibe alostericamente SERT. Se absorbe mejor con comida
Tx TOC, tept, #1 depresion mayor y panico
ES: Disregulacion gluc, hepatotoxicidad

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5
Q

Citalopram

A

Inhibidor de la recaptura de serotonina
Tx sd disforico premenstrual, efecto neuroprotector en enf parkinson, depresion mayor
ES: sd serotoninergico, predispone arritmias, disf sexual
CI: px con sd de QT largo

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6
Q

Escitalopram

A

Inhibidor de la recaptura de serotonina
Tx trastorno de panico o angustia, TAG (ISRS + ansiolitico), mejora patron de sueño en adultos mayores
ES: Sd serotoninergico

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7
Q

Venlafaxina

A

Inhibidores de recaptura de noradrenalina y serotonina
Tx #1 DEPRESION x CA DE MAMA, #1 TEPT, control de dolor neuropatico, control de sx vasomotores de menopausia, depresion mayor y ansiedad
ES: Dism peso (no en trastorno alimenticio), sd serotoninergico, abstinencia intensa, hipertension diastolica sostenida, inhibidor debil cyp2d6
CI: embarazo

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8
Q

Desvenlafaxina

A

Inhibidores de recaptura de noradrenalina y serotonina
Tx fibromialgia, neuropatia diabetica
Inhibidor debil de cyp2d6

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9
Q

Duloxetina

A

Inhibidores de recaptura de NA y serotonina
Union alta a proteinas
Tx fibromialgia, neuropatia diabetica, dolor neuropatico, dolor por osteoartritis, depresion mayor, ansiedad, incontinencia urinaria de esfuerzo en mujeres

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10
Q

Milnacipran

A

Inhibidor de recaptura de NA y serotonina

Tx depresion mayor + fibromialgia

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11
Q

Bupropion

A

Atipicos
Inhibe recaptacion de NET y DAT, NO INTERFIERE con disf sexual
Tx ansias de abstinencia de nicotina, trastorno depresivo estacional, TDAH, depresion mayor, dolor neuropatico, bajar de peso
CI: px con convulsiones ni trastorno alimenticio

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12
Q

Mirtazapina

A

Atipicos
Antagonista A2 (fuerza NE), antagonista H1 (efecto sedante + potente de todos), receptor de 5HT2, NO AFECTA SEXUAL
Tx depresion e insomnio
ES: Aum apetito, aum peso (dar bulimia y anorexia), agranulocitosis

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13
Q

Atomoxetina

A

Atipicos
Antagonista NET
Tx en pediatria para TDAH

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14
Q

Trazodona

A

Atipicos
Antagonista receptor 5HT2A en dosis bajas y altas agonista y A1
Tx depresion mayor con insomnion
ES: priapismo, hipnosis, hipotension ortostatica
CI: NO con IMAO

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15
Q

Nefazodona

A

Atipicos
Receptor 5HT2A
Tx insomnio y depresion
ES: hepatotoxicidad y priapismo

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16
Q

Desipramina

A

ATC, 2da gene
Antagonista NET
Tx sd de Tourette. TDAH, depresion mayor

17
Q

Amoxapina

A

ATC, 2da gene
Antagonista de DA y NET
Tx depresion mayor melancolica
ES: parkinson, discinesia tardia

18
Q

Nortriptilina

A

ATC, 2da gene

Enuresis nocturna en niños

19
Q

Protriptilina

A

ATC, 2da gene
Antagonista SERT y NET
Tx depresion y ansiedad, enuresis

20
Q

Doxepina

A

ATC, 3era gene

Tx prurito, insomnio, trastornos dolorosos

21
Q

Clorimipramina

A

ATC, 3era gene

TOC resist

22
Q

Imipramina

A

ATC, 3era gene
Tx enuresis, antagonista A1, NO en viejitos x hipotension ortostatica
*Ataques de panico y dolor neuropatico

23
Q

Amitriptilina

A

ATC, 3era gene

Dolor cronico o neuropatico, cefalea migrañosa, insomnio

24
Q

Selegilina

A

IMAO
REVERSIBLE
Tx etapas iniciales del parkinson o coadyuvante con levodopa, no tanto antidepre

25
Q

Tranilcipromina/isocarboxazida/fenelzina

A

IMAO
IRREVERSIBLES
Metabolizan por acetilacion, produce mareos
Tx depresion atipica, no endogeno o neurotico, trastorno depresivo mayor resistente a tx

26
Q

Litio

A

Tx bipolaridad y manias
Inhibe recambio de fosfolipidos e interactua con GABA y bloquea ip3
ES: cardiopatia congenita asociada a su uso (epstein), consumir sodio, hipotiroidismo, diabetes insipida, temblor fino, mareo, fatiga
CI: cardiopatia o en tx con diureticos

Farma 3eras (24 decks)

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