8 Flashcards
how can risk of organ transplant rejection be reduced
ABO compatible
recipient must not have anti-donor HLA ABs
donor should be selected with as close a HLA match as possible
immunosuppressive treatment
clinical signs on investigations of hereditary spherocytosis
DAGT negative
bilirubin and LDH high
reticulocyte count high
spherocytosis
presence in the blood of spherocytes, i.e erythrocytes that are sphere-shaped rather than bi-concave disk shaped as normal
function of HLA class 1
present foreign antigens to T cells
consequences of HbS polymerisation
- red cell injury
- haemolysis
- promotion of inflammation
- coagulation activity
- dysregulation of vasomotor tone
- vaso occlusion
describe homozygous beta thalassaemia
- no beta chains
- transfusion dependant anaemia
thrombocytosis
too many platelets
eltrombopeg
thrombopoietin receptor agonist that binds to and activates thrombopoeitin receptor, increasing platelet production
romiplostim
Fc-peptide fusion protein that binds to and activates thrombopoietin receptor, thereby increasing platelet production
platelet agonists that can be used therapeutically
romiplostim and eltrombopeg
function platelets
haemostasis
where are platelets produced
liver
what regulates platelet production
thrombopoeitin
increased loss causes of anaemia
- haemorrhage
- menorrhagia
- GI bleed
- haemolysis
anaemia
reduction in red cell numbers or their haemoglobin content
