13 Flashcards
serum ferrtin indicates
body iron store levels
what does a low reticulocyte count indicate
aplastic anaemia
bone marrow tumour
aplastic anaemia
serious condition affecting the blood, where the bone marrow and stem cells do not produce enough blood cells. It is also called bone marrow failure and can happen suddenly (acute) or develop over a period of time (chronic).
function reticulocyte count
tell you if bone marrow working properly
causes normochromic normocytic anaemia
- acute blood loss
- haemolysis
- secondary anaemia
- hypoplasia
define hypochomic microcytic anaemia
cells are small and pale
low MCV and MCH
what is A antigen made of
N-acetyl-galactosamine
what is B antigen made of
galactose
congenital causes haemolytic anaemia
- hereditary spherocytosis
- G6PD deficiency
- haemoglobinopathy
DAGT
direct antoiglobulin test
investigations haemolytic anaemia
blood film
FBC
reticulocyte count
serum bilirubin
for FFP, what group can A have
A and AB
signs of bone marrow failure
- anaemia
- infections
- hypercalcaemia
- renal failure
- bone disease
signs of bone disease
anaemia patholgical fractures hypercalcaemia cord compression lytic bone lesions
investigations if Wells score high/ D-dimer +
- doppler of leg
- CTPA
- CT venogram
- VQ scan
lab testing if Wells score low
d dimer
predicted investigation results in ALL
haemoglobin low
WCC high
platelets low
bone marrow 90% B lymphoblasts
define type 1 vWD
quantitive deficiency
presentation essential thrombocythaemia
symptoms of arterial and venous thrombosis digital ishcaemia gout headache mild splenomegaly
where are B cells produced and matured
bone marrow
haemorrhagic diathesis
unusual susceptibility to bleed
management of DIC in a patient if not actively bleeding
low doses of anticoagulation
