11

Question 1

management mild primary immunodeficiency

Answer 1

Practice good hygiene
healthy diet
exercise
sleep hygiene 
avoid stress
Avoid exposure.
receive appropriate vaccinations

Question 2

common infections in severely lymphopenic patients

Answer 2

• PJP
• aspergillosis
• candida
• EBV
• HSV mouth ulcers
• shingles

Question 3

significant risk factors for infection in haematological malignancy

Answer 3

• neutropenia
• disrupted skin/ mucosa
• altered flora
• antibiotic resistance
• lymphopenia
• monocytopenia

Question 4

indications for cryoprecipitate

Answer 4

thrombocytopenia
DIC with bleeding
thrombotic therapy
renal or liver failure
inherited hypofibringenaemia

Question 5

cryoprecipitate

Answer 5

insoluble material that comes out of solution after frozen plasma is thawed at 4°C (between 1 and 6°C). It is rich in certain plasma proteins, especially fibrinogen

Question 6

define stage A CLL

Answer 6

<3 lymph node areas

Question 7

chronic lymphocytic leukaemia

Answer 7

slow developing blood cancer

bone marrow makes too many lymphocytes

Question 8

management leukaemia in pregnancy after 32 weeks

Answer 8

elective delivery to allow chemotherapy to begin

Question 9

presentation chronic lymphocytic leukaemia

Answer 9

can be asymptomatic at presentation

• anaemia
• lymohadenopathy
• thrombocytopenia
• weight loss
• splenomegaly
• fever and sweats

Question 10

risk to mother of leukaemia in pregnancy

Answer 10

delay in treatment - more advanced cancer
untreated AML is fatal within months
any deterioration in maternal health is often accompanied by foetal death

Question 11

after red cell break down what happens to the haem group

Answer 11

bilirubin

Question 12

myeloma

Answer 12

neoplastic disorder of bone marrow, of plasma cells, usually resulting in excessive production of a single type of immunoglobulin

Question 13

where does red cell breakdown occur

Answer 13

reticuloendothelial system

spleeeeeeeeeen :)))))

Question 14

vitamins involved in red cell production

Answer 14

B12
folic acid
thiamine
B6
C
E

Question 15

haemoglobin reference value female >70

Answer 15

108-143

Question 16

Mean Cell Volume

Answer 16

cell size

Question 17

mean cell haemoglobin

Answer 17

colour of cell

Question 18

anaemia presentation

Answer 18

fatigue 
pale palor
SOB
dizzy
chest pain
ankle swelling

Question 19

causes of decreased production of red cells/ haemoglobin

Answer 19

• bone marrow failure
• deficiency of iron, folate, B12
• diet malabsorption e.g. coeliac, crohns
• pernicious anaemia

Question 20

prevention haemolytic disease of newborn

Answer 20

prophylactic anti-D routine @ 28/40 in rhesus negative mother

Question 21

presentation haemolytic disease of newborn

Answer 21

heart failure
respiratory distress
oedema
jaundice

Question 22

features chronic myeloid leukaemia

Answer 22

• leukaemic cells retain ability to differentiate
• proliferation without bone marrow failure
• long term survival possible