15 Flashcards
blood group B have antibodies against
A
hodgkin lymphoma investigations
blood film bone marrow biopsy lymph node biopsy FBC PET scan CT MRI CXR
describe high grade Non-hodgkins lymphoma
diffuse large B cell
aggressive, fast growing
can be cured
management hodgkin lymphoma
combination of chemo and radio therapy
monoclonal antibodies
immunotherapy
describe low-grade lymphoma
follicular, marginal zone
leave alone if causing problems
often asymptomatic
can’t be cured
management non-hodgkin lymphoma
combination chemo
what temp red blood cells kept at
4*c
lymphoma
cancer of lymphoid origin
what does presence of paraprotein indicate
monoclonal proliferation of B cell/ plasma cells somewhere in the body
only found in presence of malignancy/ disease
what is involved in a screening for blood donors
sex age travel tattoos ABO Hep B/C/E HIV syphilis
what does IgM paraprotein presence indicate
lymphoma
what does IgG, IgA paraprotein presence indicate
myeloma
indications for red cell transfusion
- correct severe anaemia
- improve QOL in uncorrectable anaemia
- prepare patient for surgery/ speed up recovery
- reverse damage caused in sickle cell for example
TACO
transfusion associated circulatory overload
TRALI
transfusion relate acute lung injury
ATR
acute transfusion reaction e.g. allergic, febrile
function electrophoresis
assesses antibody diversity
identifies paraprotein
