5

Question 1

what type of drug is clopidogrel

Answer 1

anti-platelet

Question 2

causes thrombocytopenia

Answer 2

marrow failure

immune destruction

Question 3

paraprotein

Answer 3

monoclonal immunoglobulin present in urine or blood

Question 4

what conditions cause thrombocytosis

Answer 4

myeloid malignancy

reactive iron deficiency

Question 5

thrombocytosis

Answer 5

excessive number of platelets in the blood

Question 6

presentation lymphoma

Answer 6

enlarged lymph nodes
or 
extranodal involvement
or 
bone marrow involvement 
or 
systemic B symptoms

Question 7

presentation acute lymphoblastic leukaemia

Answer 7

2-3 weeks of
fatigue
weakness
bruising 
bleeding
infection 
bone pain
sweats
weight loss
hepatosplenomegaly

Question 8

most common age presentation ALL

Answer 8

<6y/o

Question 9

management beta thalassemia major/ homozygous beta thalassaemia

Answer 9

bone marrow transplant

chronic transfusion support:

• 4-6 weekly
• normal development
• death in 2nd/3rd decade of life if iron loading left untreated

Question 10

how is iron overload managed

Answer 10

iron chelation therapy

drugs bind to excess iron enabling it to be excreted

Question 11

describe ALL

Answer 11

cancer of lymphoid progenitor cells
no differentiation
rapid uncontrolled growth and accumulation
disease of bone marrow but can enter blood

Question 12

mangement dyspnoea after transfusion

Answer 12

O2
diuretic
ventilation
adrenaline

Question 13

management urticaria

Answer 13

anti-histamine

adrenaline

Question 14

examples of antipyretics

Answer 14

NSAIDs
paracetamol
aspirin

Question 15

describe thalassaemia minor

Answer 15

carrier state
asymptomatic
cells are a little pale

Question 16

function G6PD

Answer 16

protects haemoglobin from oxidative damage

Question 17

where is G6PD deficiency most common and why

Answer 17

areas of high malaria prevelance

confers protection against p.falciparum

Question 18

G6PD deficiency causes

Answer 18

x-linked
affects males
females carried

Question 19

presentation type 1 vWD

Answer 19

• mildest

- bleeding mostly only a problem if they have surgery/ injure themselves

Question 20

management folate deficiency

Answer 20

oral folic acid

Question 21

causes of folate deficiency

Answer 21

dietary
haemolysis
GI e.g. coeliac
pregnancy