1 Flashcards
leukostasis
when blast cells over run the blood
medical emergency
most commonly seen in AML
cause decreased tissue perfusion
what abnormality would be seen on a bone marrow slide in AML
high numbers blast cells
what is the cause of issues in venous thrombosis
back pressure of blood
presentation bone marrow failure
anaemia
thrombocytopenic bleeding
infection due to neutropenia
low neutrophils with high/ normal WCC
causes AML
- previous chemo/ radio
- exposure to increased levels of radiation
- smoking
- Downs
- increasing age
presentation sick cell chest crisis
worsening hypoxia
fever
chest pain
infiltrates on x-ray
describe sickle cell chest crisis
The acute chest syndrome is a vaso-occlusive crisis of the pulmonary vasculature commonly seen in people with sickle cell anemia. This condition commonly manifests with a new opacification of the lung(s) on a chest x-ray.
management haemorrhagic disease of newborn
completely preventable with administration of vit K at birth
management essential thrombocytosis
- aspirin
- hydroxycarbamide chemo
- anagrelide
what is essential thrombocytosis
myeloproliferative disease with prominent feature raised platelet count
pretest probability score for DVT/ PE
Wells
what makes up a venous thrombosis
‘red thrombus’
platelets, fibrin and red cells
management polycythaemia vera
- venesection
- blood letting
- aspirin
- hydroxycarbamide chemo
- ruxolitinib
management myelofibrosis
hydroxycarbamide
thalidomide
ruxolitinib
myelodysplastic syndromes
groups of diseases in which bone marrow does not make enough healthy mature blood cells
