6

Question 1

acquired causes haemolytic anaemia

Answer 1

HELLP
autoimmune
severe infection
DIC

Question 2

ferroportin

Answer 2

transports iron across basement membrane

Question 3

describe role of hepcidin

Answer 3

synthesised in hepatocytes in response to increase in iron

blocks ferroportin reducing intestinal absorption and mobilisation from reticuloendothelial cells

Question 4

what is iron stored as and where

Answer 4

ferritin

liver

Question 5

describe pathway for excreting excess iron

Answer 5

doesn’t exist

Question 6

causes of macrocytic anaemia

Answer 6

B12/ folate deficiency

Question 7

cause hypo chromic microcytic anaemia

Answer 7

iron def anaemia
thalassaemia
secondary anaemia

Question 8

presentation Beta Thalassaemia major

Answer 8

• severe anaemai
• presents between 3->6 months
• failure to thrive
• expansion of ineffective bone marrow
• bony deformities
• splenomegaly
• growth retardation

Question 9

timeline acute GVHD

Answer 9

up to 4 weeks after SCT

Question 10

presentation Hodgkin lymphoma

Answer 10

fever
persistent cough/ SOB
pruritus 
unintentional weight loss
lymph swelling
night sweats

Question 11

when is 1st peak lymphomas

Answer 11

15->35years

Question 12

is Hodgkin or non-hodgkin a specific disease

Answer 12

hodgkin

Question 13

poor prognostic markers CLL

Answer 13

• advanced disease
• atypical lymphocyte mrophology
• rapid lymphocyte doubling time

Question 14

indications for treatment CLL

Answer 14

• progressive bone marrow failure
• massive lymphadenopathy
• progressive splenomegaly
• lymphocyte doubling time <6 months/ or 50% increase in 2/12
• systemic symptoms
• autoimmune cytopenia

Question 15

triggers to haemolytic in G6PD

Answer 15

acute illness e.g. DKA
broad beans 
antimalarials 
sulphonamides 
aspirin 
vit K analogues
methylene blue

Question 16

cryoprecipitate

Answer 16

frozen blood product prepared from plasma

Question 17

typical WCC

Answer 17

4-10x10^9

Question 18

typical platelet level

Answer 18

150-400x10^9

Question 19

blood issues associated with RA

Answer 19

• anaemia of chronic disease
• iron deficiency due to NSAIDs
• folate deficiency (diet and methotrexate)
• immune haemolytic
• neutrophilia
• immune thrombocytopenia
• cytopenias

Question 20

function HLA/MHC class 2

Answer 20

displays antigens eaten by B lymphocytes

Question 21

inflammatory causes neutrophilia

Answer 21

• MI
• post op
• RA

Question 22

infectious causes neutrophilia

Answer 22

any infections but especially pyogenic