5.1 Classification And MOA Of Hormones Flashcards

0
Q

Steroid like amino acid derivative hormones

A

T3 and t4 (iodothyronines)

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1
Q

First step in amplification of the hormonal response

A

Receptor-effector coupling

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2
Q

Amino acid derivative hormones that are peptide-like

A

Catecholamines

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3
Q

Group classification of hormones that are lipophilic, use intercellular receptors, and have long plasma half life

A

Group I (steroids, retinoids, calcitriol, and iodothyronines)

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4
Q

Group classification of hormones that are hydrophilic, with short plasma half life, use plasma membrane receptors

A

Group II (polypeptides, proteins, glycoproteins, Catecholamines)

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5
Q

Glucocorticoid receptors are found in the

A

Cytoplasm

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6
Q

Receptors for t3, t4, and retinoic acids are found in the

A

Nucleus

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7
Q

Two hormones with cGMP as second messengers

A

Atrial natriuretic factor and nitric oxide

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8
Q

Feature of signal transduction where signal molecule only fits in its complementary receptor

A

Specificity

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9
Q

Feature of signal transduction where enzymes activate enzymes and the number of affected molecules increase geometrically

A

Amplification

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10
Q

Signal transduction feature where receptor activation triggers a feedback circuit that shuts off the receptor or removes the receptor from the cell surface

A

Desensitization or adaptation

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11
Q

Function of GAPs

A

Increase GTPase activity and determines how long the switch remains on
Inactivated the protein

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12
Q

Function of GEFs

A

Exchanges bound GDP with GTP

Activates G protein

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