5.1 Classification And MOA Of Hormones Flashcards
Steroid like amino acid derivative hormones
T3 and t4 (iodothyronines)
First step in amplification of the hormonal response
Receptor-effector coupling
Amino acid derivative hormones that are peptide-like
Catecholamines
Group classification of hormones that are lipophilic, use intercellular receptors, and have long plasma half life
Group I (steroids, retinoids, calcitriol, and iodothyronines)
Group classification of hormones that are hydrophilic, with short plasma half life, use plasma membrane receptors
Group II (polypeptides, proteins, glycoproteins, Catecholamines)
Glucocorticoid receptors are found in the
Cytoplasm
Receptors for t3, t4, and retinoic acids are found in the
Nucleus
Two hormones with cGMP as second messengers
Atrial natriuretic factor and nitric oxide
Feature of signal transduction where signal molecule only fits in its complementary receptor
Specificity
Feature of signal transduction where enzymes activate enzymes and the number of affected molecules increase geometrically
Amplification
Signal transduction feature where receptor activation triggers a feedback circuit that shuts off the receptor or removes the receptor from the cell surface
Desensitization or adaptation
Function of GAPs
Increase GTPase activity and determines how long the switch remains on
Inactivated the protein
Function of GEFs
Exchanges bound GDP with GTP
Activates G protein