3.10 Phospholipid Biosynthesis

Question 1

Enzymes in the synthesis of phosphatidylcholine and phosphatidylethanolamine

Answer 1

DHAP into glycerol 3 phosphate (glycerol 3 phosphate dehydrogenase)
Glycerol 3 phosphate into phosphatidate (glycerol phosphate transyclase)
Phosphatidate into 1,2-diacylglycerol (phosphatidate phosphatase)
Phosphocholine/phosphoethanolamine (choline/ethanolamine kinase)
CDP choline/ CDP ehtanolamine (Cytidine triphosphate)
transfered to c3 of 1,2 diacylglycerol (phosphocholine/phosphoethanolamine diacylglycerol transferase)

Question 2

Catalyzes the interconversion of PE and PS

Answer 2

Base Exchage:
-Phosphatiduulethanolamine: serine transferase
Minor pathway:
-decarboxylation of PS via phosphatidulserine decarboxulase

Question 3

Reacts with phospatidate to form and activated diacylglycerol, cytudube diphosphate diacylglycerol

Answer 3

CTP or cytidine triphosphate

Question 4

Phospholipase that cleaves FA from C1 of glycerol backbone

Answer 4

Phospholipase A1

Question 5

Phospholipase that cleaves FA from C2 of glycerol backbone

Answer 5

Phospholipase A2

Question 6

Activates Phospholipase A2

Answer 6

Trypsin

Question 7

Inhibits Phospholipase

Answer 7

glucocorticoids

Question 8

Phospholipase present in liver lysosomes that release phosphorylated alcohol form c3 of glycerol backbone

Answer 8

Phospholipase C

Question 9

Phospholipase involved primarily in plant tissue that releases alcohol attached to the phosphate group of phosphoglycerol molecule

Answer 9

Phospholipase D