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Biochemistry > 1.10 RBC Metabolism > Flashcards

1.10 RBC Metabolism Flashcards

1
Q

Total blood volume

A

5-6 liters

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2
Q

Whole blood minus the formed elements

A

Plasma

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3
Q

Whole blood minus formed elements and clotting factors

A

Serum

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4
Q

Normal RBC count for ment

A

5-6 million/mm3

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5
Q

Normal RBC count for women

A

4-5 million/mm3

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6
Q

Normal life span of RBCs

A

90-120 days

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7
Q

Controls RBC production

A

Erythropoietin by the kidneys

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8
Q

Ankyrin binds to integral protein ___

A

Band 3

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9
Q

Actin binds to peripheral protein ___

A

Band 4.1

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10
Q

integral protein important for anion exchange

A

Band 3

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11
Q

Proteins that help shape and allow flexibility of the RBC

A

Peripheral proteins

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12
Q

Gives the cell membrane its strength and flexibility

A

Spectrin

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13
Q

RBC membrane transporter that is insulin dependent

A

GLUT-1

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14
Q

The A antigen in blood type A has an extra ___

A

GalNAc

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15
Q

The B antingen in blood type B has an extra __

A

Gal

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16
Q

RBC metabolism of glucose via anaerobic glycolysis

A

Embden-Meyerhoff Pathway

17
Q

RBC metabolism of glucose via Pentose Phosphate Pathway; aerobic

A

Hexose Monophosphate Shunt

18
Q

Enzyme responsible for the conversion of phosphoenolpyruvate to pyruvate is ___

A

Pyruvate kinase

19
Q

Enzyme responsible for the conversion of Pyruvate to lactate is ___

A

L-lactate dehydrogenase

20
Q

Enzyme responsible in converting G6P to 6-phosphogluconate then to ribulose 5-phosphate

A

G6P dehydrogenase

21
Q

Enzyme responsible for converting 1,3 diphosphoglycerate to 2-3 diphosphoglycerate

A

diphosphoglycerate mutase

22
Q

Enzyme responsible for converting 2,3-DPG to 3 phosphoglycerate

A

2,3 BPG phosphatase

23
Q

RBC disorder due to abnormalities in spectrin

A

Hereditary elliptocytosis

24
Q

A genetic defect caused partial or total absence by one or more alpha or beta chains of hemoglobin

A

Thalassemia

25
Q

Heme is the prosthetic group of ___ in the liver

A

Cytochrome p450

26
Q

rate controlling enzyme in heme biosynthesis

A

Ala synthase

27
Q

Steps and enzymes in heme biosynthesis

A

Enzymes:ALA synthaseALA dehydrataseHMB synthaseUroporphyrinogen III synthaseUroporphyrinogen decarboxylaseCoproporphyrinogen oxidaseProtoporphyrinogen oxidaseFerrochelatase

28
Q

Group of disorders caused by abnormalities in the pathway of biosynthesis of heme

29
Q

Also known as bone marrow failure where the body doesnt make enough RBCs, WBCs, and platelets

A

Aplastic anemia

30
Q

Hemoglobinopathy with increased concentration of erythrocytes

A

Polycythemia vera

31
Q

Hemoglobinopathy characterized by large cells with increased nuclear/cytoplasmic ratio

A

Megaloblastic enmia

32
Q

Hemoglobinopathy characterized by small and pale red blood cells due to iron deficiency

A

Vitamin B6 or iron-deficiency anemia

Biochemistry (29 decks)

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