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Biochemistry > 1.6 Immunity and Complement > Flashcards

1.6 Immunity and Complement Flashcards

1
Q

Pathogen for tlr1-2

A

Fungi

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2
Q

Pathogen for tlrs 3,7,8

A

Viruses

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3
Q

Pathogen for tlr 4

A

Gram + bacteria

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4
Q

Pathogen for tlrs 5,9,10

A

Bacteria

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5
Q

Cytokines shared by both innate and adaptive immunity

A

IL 4, IL 6, and INF

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6
Q

Ig best at opsonization

A

IgG1

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7
Q

Ig best at sensitization by mast cells

A

IgE

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8
Q

Ig best at activation of complement system

A

IgM and IgG3

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9
Q

Ig that can transport through epithelium

A

IgA

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10
Q

Ig that can transport through placenta

A

IgG

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11
Q

Ig that cannot diffuse into extravascular sites

A

IgD

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12
Q

Major Ig in serum

A

IgG

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13
Q

Agglutinating IgEfficient in leading the lysis of microorganismsFirst to be made by fetus virgin b cells after stimulation by an antigen

A

IgM

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14
Q

2nd most common serum IgIn secretions, including colostrum

A

IgA

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15
Q

Ig primarily found in B cell surfacesFunctions as receptor for antigensHas extra amino acids at c terminal which anchors to membranesDoes not bind complement

A

IgD

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16
Q

Least common serum IgInvolved in allergic reactionsPlay a role in parasitic helminthsDoes not fix complement

A

IgE

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17
Q

Ig mediator for immediate hypersensitivity

A

IgE

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18
Q

Ig mediator for antibidy-mediated hyperaensitivity

A

IgG and IgM and complement

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19
Q

Ig mediator for immune complex-mediated hypersensitivity

A

IgG and complement

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20
Q

Ig mediator for delayed sensitivity

A

T cells, macrophages, histiocytes

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21
Q

Functions to activate cells including-innate immune system-b lymphocytes-cytotoxic t cells-nonimmune cellsCritical role in suppression of immune reaction

A

Cd4+ t cells

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22
Q

Function of cd4+ helper t cells

A

Secrete cytokines

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23
Q

CD4+ helper t subsets that functions to secrete cytokines thatSuppress tumor immunityPromotes immune toleranceMaintains lymphocyte homeostasis

A

TregTGF-BIL-10IL-35STAT6FOXP3

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24
Q

CD4+ helper t subsets that functions to secrete cytokines thatPromotes tumor immunityIntracellular pathogens immunityDrives autoimmunity

A

Th1IFB-yLTaSTAT4T-bet

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25
Q

CD4+ helper t subsets that functions to secrete cytokines thatMediates allergy, asthma, and extracellular immunity

A

Th2IL-4IL-5IL-13STAT6GATA3

26
Q

CD4+ helper t subsets that functions to secrete cytokines thatMediate controversial tumor immunityBreaks immune toleranceFight extracellular bacteriaAutoimmunuty

A

Th17

27
Q

Function of CD8+ T cells

A

Kill infected cells containing cytoplasmic microbes

28
Q

Phases of CD8+ T cells action

A

Recognition of MHC-I associated peptide antigensDegranulation of CTLsRelease of perforinsPerforins activate caspasesApoptosis

29
Q

Key component of the C4b2a (c3 convertase) complex

A

C4

30
Q

Serine proteinase which activates factor b

A

Factor D

31
Q

Stabilizes the C3bBb complex

A

Properdin

32
Q

Key component for both amplification step generation if C5 convertase activity

A

c3

33
Q

Components of the membrane attack complex

A

C5-9

34
Q

First component of the MAC

A

C5

35
Q

Binds C5b and C7 in the MAC

A

C6

36
Q

Binds c7 and c8 in the MAC

A

C7

37
Q

Binds c8 and c9

A

C8

38
Q

Polymerises to firm large membrane pore

A

C9

39
Q

Initiators of the classical complement pathway

A

Immune complexesApoptotic cellsCertain viruses and gram(-) bacteriaC-reactive protein bound to ligand

40
Q

Initiator of mannose-binding lectin pathway

A

Microbes with terminal mannose groups

41
Q

Initiator of alternative complement pathway

A

Many bacteria, fungi, viruses, and tumor cells

42
Q

Effector function of c5a and C3a

A

InflammationRecruitment and activation of leukocytesDestruction of microbes by leukocytes

43
Q

Effector function of c3b

A

Phagocytosis

44
Q

Effector function of MAC

A

Lysis of microbe

45
Q

First cell type to arrive at the injury site

A

Neutrophils

46
Q

Oxidative burst machinery

A

NETs or neutrophil extracellular traps

47
Q

Cytokine that stimulates eosinophil development and differentiation

A

IL-5

48
Q

Release proinflammatory mediatora

A

Eosinophils

49
Q

Ensures that distinct antigens elicit responses that target those antigens

A

Specificity

50
Q

Enables immune system to respond to a large variety of antigens

A

Diversity

51
Q

Leads to rapid and enhanced responses to repeated exposures to the same antigens

A

Memory

52
Q

Increases number of antigen-specific lymphocytes to keep pace with microbes

A

Clonal expansion

53
Q

Generates responses that are optimal for defense against different types of microbes

A

Specialization

54
Q

Precursor of tissue macrophages

A

Neutrophils

55
Q

Heterogenous group of immunicompetent cells that mediate the cellular immune response by processing and presneting antigens ti the t cells.

A

APCs

56
Q

Transmembrane proteins that revignize invading microbes and activate signaling pahtways that kaunch immune and inflammatory responses to destroy the invaders

A

Toll-like receptors

57
Q

Pathogen for tlr 2-6

A

Gram + bacteriaFungiMycobacteria

58
Q

Major Ig in serum and extracellular spaces; most abundant among newborns; predominant antibody in secondary response

A

IgG

59
Q

Agglutinating Ig and complement fixing Ig; lysis of microorganisms; first produced by naive B cells in primary immune response; J chain

A

IgM

60
Q

2nd most common Ig in serum

A

IgA

Biochemistry (29 decks)

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