3.4 B Oxidation of Fatty Acids

Question 1

Oxidation of fatty acids occur in the:

Answer 1

Mitochondria

Question 2

In the plasma, long chain fatty acids are combined with

Answer 2

Albumin

Question 3

Cannot utilize fatty acids because they dont have mitochondria

Answer 3

RBC

Question 4

Activates fatty acids before being utilized or oxidized

Answer 4

Fatty Acyl Coa Synthetase

Question 5

Only step in fatty acid degradation that requires energy from ATP

Answer 5

Activation of fatty acid via Fatty Acyl Coa synthetase

Question 6

Product of fatty acyl coa synthetase

Answer 6

Activated fatty acid (fatty acyl coa) and releases Fatty acyl-AMP and pyrophosphate (PPi)

Question 7

Serves as the fatty acyl carrier transporter across the inner mitochondrial membrane

Answer 7

Carnitine

Question 8

Converts long chain fatty acyl-coa to acylcarnitine

Answer 8

Carnitine palmitoyltransferase I (outer mitochondrial membrane)

Question 9

An inner membrane exchange transporter which exchanges acylcarnitine for carnitine

Answer 9

Translocase

Question 10

Catalyzes reaction of acylcarnitine with CoA, reforming acyl-CoA in the mitochondrial matrix, ready for oxidation

Answer 10

Carnitine palmitoyltransferase II (inner mitochondrial membrane)

Question 11

Inhibits the formation of fatty acyl carnitine derivatives

Answer 11

Malonyl-CoA

Question 12

For every two carbons oxidized, these are the steps repeated:

Answer 12

Dehydrogenation
Hydration
Oxidation
Thiolysis

Question 13

Total number of ATPs produced in beta oxidation of long chain FAs

Answer 13

5

Question 14

Beta oxidation of odd chain fatty acicd produces __ after cleavage by thiolase

Answer 14

Acetyl-CoA and pripionyl coa

Question 15

Carboxylation of propionyl coa yields

Answer 15

Methylmalonyl coa which is converted to succinyl-coa

Question 16

Enzymes for beta oxidation of odd chain FAs

Answer 16

Propionyl coa carboxylase
Methylmalonyl coa racemase
methylmalonyl coa mutase

Question 17

Additional enzymes needed for oxidation of unsaturated fatty acids

Answer 17

Isomerase and a reductase (hydratase)

Question 18

Action of glucagon on malonyl coa

Answer 18

Inhibits the formation of malonyl coa which then stimulates carnitine acyltransferase I

Question 19

Action of insulin on malonyl coa

Answer 19

Stimulates formation of malonyl CoA

Question 20

Synthesizes malonyl coa

Answer 20

Acetyl-CoA carboxylase